Entity Details

Name ALK
ID Q9UM73
Role substrate
Enzymatic Domains
MAM 1 264-427
PROSITE-ProRule
LDL-receptor class A 437-473
MAM 2 478-636
PROSITE-ProRule
Protein kinase 1116-1392
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ALKALKTyr1278FGMARDIyRASYYRKphosphorylation
up-regulates activity		15938644SIGNOR-250575
PTPRZ1ALK–dephosphorylation
down-regulates		17681947SIGNOR-157227
PTPRBALK–dephosphorylation
down-regulates		17681947SIGNOR-157175
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ALKphosphorylation
up-regulates
→
ALK
PTyr1278		phosphorylation
up-regulates
→		ALK15938644SIGNOR-250575
Regulator Mechanism/Effect Target SIGNOR-ID
ALKphosphorylation
→
up-regulates activity 		ALKSIGNOR-250575
PTPRZ1dephosphorylation
img/direct_inhibition.png
down-regulates 		ALKSIGNOR-157227
PTPRBdephosphorylation
img/direct_inhibition.png
down-regulates 		ALKSIGNOR-157175