| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NEK2 | SUFU | – | phosphorylation up-regulates activity | 27297360 | SIGNOR-279235 | |
| PRKACA | SUFU | Ser346 | RAPSRKDsLESDSST | phosphorylation up-regulates quantity by stabilization | 21317289 | SIGNOR-172003 |
| PRKACA | SUFU | Ser342 | LAHDRAPsRKDSLES | phosphorylation up-regulates | 23337587 | SIGNOR-200492 |
| PRKACA | SUFU | Ser342 | LAHDRAPsRKDSLES | phosphorylation up-regulates quantity by stabilization | 21317289 | SIGNOR-171999 |
| PRKACA | SUFU | Ser346 | RAPSRKDsLESDSST | phosphorylation up-regulates | 21317289 | SIGNOR-200496 |
| PRKACA | SUFU | Ser346 | RAPSRKDsLESDSST | phosphorylation up-regulates | 23337587 | SIGNOR-119099 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | SUFU PSer346 | phosphorylation up-regulates → | SUFU | 21317289 | SIGNOR-172003 |
| PRKACA | phosphorylation up-regulates → | SUFU PSer342 | phosphorylation up-regulates → | SUFU | 23337587 | SIGNOR-200492 |
| PRKACA | phosphorylation up-regulates → | SUFU PSer342 | phosphorylation up-regulates → | SUFU | 21317289 | SIGNOR-171999 |
| PRKACA | phosphorylation up-regulates → | SUFU PSer346 | phosphorylation up-regulates → | SUFU | 21317289 | SIGNOR-200496 |
| PRKACA | phosphorylation up-regulates → | SUFU PSer346 | phosphorylation up-regulates → | SUFU | 23337587 | SIGNOR-119099 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NEK2 | phosphorylation → up-regulates activity | SUFU | SIGNOR-279235 |
| PRKACA | phosphorylation → up-regulates quantity by stabilization | SUFU | SIGNOR-172003 |
| PRKACA | phosphorylation → up-regulates | SUFU | SIGNOR-200492 |
| PRKACA | phosphorylation → up-regulates quantity by stabilization | SUFU | SIGNOR-171999 |
| PRKACA | phosphorylation → up-regulates | SUFU | SIGNOR-200496 |
| PRKACA | phosphorylation → up-regulates | SUFU | SIGNOR-119099 |
