Entity Details

Name CDC14A
ID Q9UNH5
Role phosphatase
Enzymatic Domains
Tyrosine-protein phosphatase 179-336
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDC14ATP53Ser315LPNNTSSsPQPKKKPdephosphorylation
down-regulates activity		10644693SIGNOR-248828
CDC14AWEE1Ser123EEGFGSSsPVKSPAAdephosphorylation
up-regulates quantity by stabilization		23051732SIGNOR-276952
CDC14AWEE1Ser123EEGFGSSsPVKSPAAdephosphorylation
up-regulates quantity by stabilization		23051732SIGNOR-267469
CDC14AWEE1Ser139YFLGSSFsPVRCGGPdephosphorylation
up-regulates quantity by stabilization		23051732SIGNOR-267470
CDC14AWEE1Ser139YFLGSSFsPVRCGGPdephosphorylation
up-regulates quantity by stabilization		23051732SIGNOR-276953
CDC14ACDC25A–dephosphorylation
down-regulates activity		20956543SIGNOR-277065
CDC14ACDC25B–dephosphorylation
down-regulates activity		20956543SIGNOR-276968
CDC14AIREB2Ser157LQKAGKLsPVKVQPKdephosphorylation
up-regulates activity		18574241SIGNOR-248829
CDC14AMAPK6Ser684IGIPQFHsPVGSPLKdephosphorylation
down-regulates		20236090SIGNOR-164404
CDC14AMAPK6Ser688QFHSPVGsPLKSIQAdephosphorylation
down-regulates		20236090SIGNOR-164408
CDC14AMAPK6Ser705TPSAMKSsPQIPHQTdephosphorylation
down-regulates		20236090SIGNOR-164412
CDC14AMAPK6Thr698KSIQATLtPSAMKSSdephosphorylation
down-regulates		20236090SIGNOR-164416
CDC14AMAPK6Ser684IGIPQFHsPVGSPLKdephosphorylation
down-regulates quantity by destabilization		20236090SIGNOR-248830
CDC14AMAPK6Ser688QFHSPVGsPLKSIQAdephosphorylation
down-regulates quantity by destabilization		20236090SIGNOR-248831
CDC14AMAPK6Ser705TPSAMKSsPQIPHQTdephosphorylation
down-regulates quantity by destabilization		20236090SIGNOR-248833
CDC14AMAPK6Thr698KSIQATLtPSAMKSSdephosphorylation
down-regulates quantity by destabilization		20236090SIGNOR-248832
CDC14ASIRT2Ser368PNPSTSAsPKKSPPPdephosphorylation
unknown		17488717SIGNOR-248834
CDC14ASPAG5–dephosphorylation
down-regulates activity		27325694SIGNOR-277066
CDC14AKMT5ASer100SKIYSYMsPNKCSGMdephosphorylation
down-regulates quantity by destabilization		20966048SIGNOR-248835
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDC14Adephosphorylation
down-regulates
⊣
TP53
PSer315		dephosphorylation
up-regulates
→		TP5310644693SIGNOR-248828
CDC14Adephosphorylation
down-regulates
⊣
WEE1
PSer123		dephosphorylation
down-regulates
⊣		WEE123051732SIGNOR-276952
CDC14Adephosphorylation
down-regulates
⊣
WEE1
PSer123		dephosphorylation
down-regulates
⊣		WEE123051732SIGNOR-267469
CDC14Adephosphorylation
down-regulates
⊣
WEE1
PSer139		dephosphorylation
down-regulates
⊣		WEE123051732SIGNOR-267470
CDC14Adephosphorylation
down-regulates
⊣
WEE1
PSer139		dephosphorylation
down-regulates
⊣		WEE123051732SIGNOR-276953
CDC14Adephosphorylation
down-regulates
⊣
IREB2
PSer157		dephosphorylation
down-regulates
⊣		IREB218574241SIGNOR-248829
CDC14Adephosphorylation
down-regulates
⊣
MAPK6
PSer684		dephosphorylation
up-regulates
→		MAPK620236090SIGNOR-164404
CDC14Adephosphorylation
down-regulates
⊣
MAPK6
PSer688		dephosphorylation
up-regulates
→		MAPK620236090SIGNOR-164408
CDC14Adephosphorylation
down-regulates
⊣
MAPK6
PSer705		dephosphorylation
up-regulates
→		MAPK620236090SIGNOR-164412
CDC14Adephosphorylation
down-regulates
⊣
MAPK6
PThr698		dephosphorylation
up-regulates
→		MAPK620236090SIGNOR-164416
CDC14Adephosphorylation
down-regulates
⊣
MAPK6
PSer684		dephosphorylation
up-regulates
→		MAPK620236090SIGNOR-248830
CDC14Adephosphorylation
down-regulates
⊣
MAPK6
PSer688		dephosphorylation
up-regulates
→		MAPK620236090SIGNOR-248831
CDC14Adephosphorylation
down-regulates
⊣
MAPK6
PSer705		dephosphorylation
up-regulates
→		MAPK620236090SIGNOR-248833
CDC14Adephosphorylation
down-regulates
⊣
MAPK6
PThr698		dephosphorylation
up-regulates
→		MAPK620236090SIGNOR-248832
CDC14Adephosphorylation
down-regulates
⊣
SIRT2
PSer368		dephosphorylation
up-regulates
→		SIRT217488717SIGNOR-248834
CDC14Adephosphorylation
down-regulates
⊣
KMT5A
PSer100		dephosphorylation
up-regulates
→		KMT5A20966048SIGNOR-248835
Regulator Mechanism/Effect Target SIGNOR-ID
CDC14Adephosphorylation
→
down-regulates activity 		TP53SIGNOR-248828
CDC14Adephosphorylation
→
up-regulates quantity by stabilization 		WEE1SIGNOR-276952
CDC14Adephosphorylation
→
up-regulates quantity by stabilization 		WEE1SIGNOR-267469
CDC14Adephosphorylation
→
up-regulates quantity by stabilization 		WEE1SIGNOR-267470
CDC14Adephosphorylation
→
up-regulates quantity by stabilization 		WEE1SIGNOR-276953
CDC14Adephosphorylation
→
down-regulates activity 		CDC25ASIGNOR-277065
CDC14Adephosphorylation
→
down-regulates activity 		CDC25BSIGNOR-276968
CDC14Adephosphorylation
→
up-regulates activity 		IREB2SIGNOR-248829
CDC14Adephosphorylation
img/direct_inhibition.png
down-regulates 		MAPK6SIGNOR-164404
CDC14Adephosphorylation
img/direct_inhibition.png
down-regulates 		MAPK6SIGNOR-164408
CDC14Adephosphorylation
img/direct_inhibition.png
down-regulates 		MAPK6SIGNOR-164412
CDC14Adephosphorylation
img/direct_inhibition.png
down-regulates 		MAPK6SIGNOR-164416
CDC14Adephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		MAPK6SIGNOR-248830
CDC14Adephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		MAPK6SIGNOR-248831
CDC14Adephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		MAPK6SIGNOR-248833
CDC14Adephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		MAPK6SIGNOR-248832
CDC14Adephosphorylation
→
unknown 		SIRT2SIGNOR-248834
CDC14Adephosphorylation
→
down-regulates activity 		SPAG5SIGNOR-277066
CDC14Adephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		KMT5ASIGNOR-248835