| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK1 | PA2G4 | Thr261 | QYGLKMKtSRAFFSE | phosphorylation up-regulates | 18283314 | SIGNOR-160963 |
| PRKCB | PA2G4 | Thr366 | QSSASRKtQKKKKKK | phosphorylation unknown | 11325528 | SIGNOR-249093 |
| PRKCA | PA2G4 | Ser363 | ALLQSSAsRKTQKKK | phosphorylation unknown | 11325528 | SIGNOR-249089 |
| PRKCD | PA2G4 | Ser360 | ELKALLQsSASRKTQ | phosphorylation up-regulates | 21145366 | SIGNOR-170348 |
| PRKCG | PA2G4 | Thr366 | QSSASRKtQKKKKKK | phosphorylation unknown | 11325528 | SIGNOR-249094 |
| PRKCG | PA2G4 | Ser363 | ALLQSSAsRKTQKKK | phosphorylation unknown | 11325528 | SIGNOR-249091 |
| PRKCB | PA2G4 | Ser363 | ALLQSSAsRKTQKKK | phosphorylation unknown | 11325528 | SIGNOR-249090 |
| PRKCA | PA2G4 | Thr366 | QSSASRKtQKKKKKK | phosphorylation unknown | 11325528 | SIGNOR-249092 |
| EIF2AK2 | PA2G4 | – | phosphorylation up-regulates activity | 16631606 | SIGNOR-279170 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK1 | phosphorylation up-regulates → | PA2G4 PThr261 | phosphorylation up-regulates → | PA2G4 | 18283314 | SIGNOR-160963 |
| PRKCB | phosphorylation up-regulates → | PA2G4 PThr366 | phosphorylation down-regulates ⊣ | PA2G4 | 11325528 | SIGNOR-249093 |
| PRKCA | phosphorylation up-regulates → | PA2G4 PSer363 | phosphorylation down-regulates ⊣ | PA2G4 | 11325528 | SIGNOR-249089 |
| PRKCD | phosphorylation up-regulates → | PA2G4 PSer360 | phosphorylation up-regulates → | PA2G4 | 21145366 | SIGNOR-170348 |
| PRKCG | phosphorylation up-regulates → | PA2G4 PThr366 | phosphorylation down-regulates ⊣ | PA2G4 | 11325528 | SIGNOR-249094 |
| PRKCG | phosphorylation up-regulates → | PA2G4 PSer363 | phosphorylation down-regulates ⊣ | PA2G4 | 11325528 | SIGNOR-249091 |
| PRKCB | phosphorylation up-regulates → | PA2G4 PSer363 | phosphorylation down-regulates ⊣ | PA2G4 | 11325528 | SIGNOR-249090 |
| PRKCA | phosphorylation up-regulates → | PA2G4 PThr366 | phosphorylation down-regulates ⊣ | PA2G4 | 11325528 | SIGNOR-249092 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK1 | phosphorylation → up-regulates | PA2G4 | SIGNOR-160963 |
| PRKCB | phosphorylation → unknown | PA2G4 | SIGNOR-249093 |
| PRKCA | phosphorylation → unknown | PA2G4 | SIGNOR-249089 |
| PRKCD | phosphorylation → up-regulates | PA2G4 | SIGNOR-170348 |
| PRKCG | phosphorylation → unknown | PA2G4 | SIGNOR-249094 |
| PRKCG | phosphorylation → unknown | PA2G4 | SIGNOR-249091 |
| PRKCB | phosphorylation → unknown | PA2G4 | SIGNOR-249090 |
| PRKCA | phosphorylation → unknown | PA2G4 | SIGNOR-249092 |
| EIF2AK2 | phosphorylation → up-regulates activity | PA2G4 | SIGNOR-279170 |
