Summary

Name PA2G4
Full Name Proliferation-associated protein 2G4
Synonyms Cell cycle protein p38-2G4 homolog, hG4-1, ErbB3-binding protein 1 | EBP1
Primary ID Q9UQ80
Links - -
Type protein
Relations 11
Function May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png sumoylation PA2G4 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PA2G4 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PA2G4 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PA2G4 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PA2G4 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PA2G4 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation KLK3 0.14
Publications: 1