Entity Details

Name CDK11A
ID Q9UQ88
Role kinase
Enzymatic Domains
Protein kinase 427-647
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK11ASPDEFSer238SEESWTDsEVDSSCSphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273020
CDK11ASPDEFSer242WTDSEVDsSCSGQPIphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273021
CDK11ASPDEFSer243TDSEVDSsCSGQPIHphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273022
CDK11ACDK11BThr726KHEYFREtPLPIDPSphosphorylation
up-regulates		21078675SIGNOR-169628
CDK11APAK1Ser174TPAVPPVsEDEDDDDphosphorylation
up-regulates activity		19520772SIGNOR-273026
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK11Aphosphorylation
up-regulates
→
SPDEF
PSer238		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273020
CDK11Aphosphorylation
up-regulates
→
SPDEF
PSer242		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273021
CDK11Aphosphorylation
up-regulates
→
SPDEF
PSer243		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273022
CDK11Aphosphorylation
up-regulates
→
CDK11B
PThr726		phosphorylation
up-regulates
→		CDK11B21078675SIGNOR-169628
CDK11Aphosphorylation
up-regulates
→
PAK1
PSer174		phosphorylation
up-regulates
→		PAK119520772SIGNOR-273026
Regulator Mechanism/Effect Target SIGNOR-ID
CDK11Aphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273020
CDK11Aphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273021
CDK11Aphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273022
CDK11Aphosphorylation
→
up-regulates 		CDK11BSIGNOR-169628
CDK11Aphosphorylation
→
up-regulates activity 		PAK1SIGNOR-273026