| + |
CDK11A | up-regulates activity 
phosphorylation
|
PAK1 |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273026 |
Ser174 |
TPAVPPVsEDEDDDD |
|
|
| pmid |
sentence |
| 19520772 |
CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression|We show that PAK1 is a substrate of CDK11p58 and can be strongly activated upon phosphorylation. |
|
| Publications: |
1 |
| + |
CDK11A | down-regulates quantity by destabilization 
phosphorylation
|
SPDEF |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273020 |
Ser238 |
SEESWTDsEVDSSCS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273021 |
Ser242 |
WTDSEVDsSCSGQPI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273022 |
Ser243 |
TDSEVDSsCSGQPIH |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CDK11A | up-regulates
phosphorylation
|
CDK11B |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169628 |
Thr726 |
KHEYFREtPLPIDPS |
Homo sapiens |
|
| pmid |
sentence |
| 21078675 |
Overall, our data indicated that thr-370 is responsible for the autophosphorylation, dimerization, and kinase activity of cdk11(p58) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK11A | form complex 
binding
|
CyclinD3/CDK11A |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273117 |
|
|
in vitro |
|
| pmid |
sentence |
| 12082095 |
Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3| |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
GADD45G | down-regulates activity
binding
|
CDK11A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273025 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
Western blot analysis for SPDEF revealed that overexpression of GADD45α, β and γ prevents SPDEF degradation mediated by CDK11p58 |We identified CDK11p58 as an interaction partner of GADD45α by co-immunoprecipitation analysis. We corroborated these data by co-immunoprecipitation in vitro translation assays, showing that all three members of the GADD45 family interact with CDK11p58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GADD45A | down-regulates activity
binding
|
CDK11A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273023 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
GADD45alpha inhibits CDK11p58 kinase activity|We identified CDK11p58 as an interaction partner of GADD45α by co-immunoprecipitation analysis. We corroborated these data by co-immunoprecipitation in vitro translation assays, showing that all three members of the GADD45 family interact with CDK11p58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GADD45B | down-regulates activity
binding
|
CDK11A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273024 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
Western blot analysis for SPDEF revealed that overexpression of GADD45α, β and γ prevents SPDEF degradation mediated by CDK11p58 |We identified CDK11p58 as an interaction partner of GADD45α by co-immunoprecipitation analysis. We corroborated these data by co-immunoprecipitation in vitro translation assays, showing that all three members of the GADD45 family interact with CDK11p58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CDK11A
- 
- 