| Name | AKT3 |
| ID | Q9Y243 |
| Role | kinase |
| Enzymatic Domains |
PH 5-107 PROSITE-ProRule
Protein kinase 148-405 PROSITE-ProRule
AGC-kinase C-terminal 406-479 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT3 | CHUK | Thr23 | EMRERLGtGGFGNVC | phosphorylation up-regulates | 19609947 | SIGNOR-187062 |
| AKT3 | TBX3 | Ser719 | AEKEAATsELQSIQR | phosphorylation up-regulates activity | 25595898 | SIGNOR-223534 |
| AKT3 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates | 19188143 | SIGNOR-183644 |
| AKT3 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates | 19188143 | SIGNOR-183648 |
| AKT3 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates | 19188143 | SIGNOR-183652 |
| AKT3 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249643 |
| AKT3 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249644 |
| AKT3 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249642 |
| AKT3 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-186780 |
| AKT3 | BRAF | Ser364 | FGQRDRSsSAPNVHI | phosphorylation down-regulates | 10869359 | SIGNOR-78693 |
| AKT3 | BRAF | Ser428 | GPQRERKsSSSSEDR | phosphorylation down-regulates | 10869359 | SIGNOR-78697 |
| AKT3 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 9829964 | SIGNOR-62257 |
| AKT3 | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251626 |
| AKT3 | BMI1 | Ser316 | ANRPRKSsVNGSSAT | phosphorylation up-regulates activity | 22505453 | SIGNOR-249583 |
| AKT3 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23552696 | SIGNOR-245424 |
| AKT3 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates | 9812896 | SIGNOR-61565 |
| AKT3 | ADAR | Thr1033 | RLGERLRtMSCSDKI | phosphorylation down-regulates activity | 31095429 | SIGNOR-276191 |
| AKT3 | ADARB1 | Thr553 | LQGERLLtMSCSDKI | phosphorylation down-regulates activity | 31095429 | SIGNOR-276195 |
| AKT3 | CYCS | Tyr47 | KTGQAPGySYTAANK | phosphorylation down-regulates activity | 32781572 | SIGNOR-277235 |
| AKT3 | POU5F1 | Thr235 | QARKRKRtSIENRVR | phosphorylation up-regulates quantity by stabilization | 23041284 | SIGNOR-242107 |
| AKT3 | STK4 | Thr387 | TMKRRDEtMQPAKPS | phosphorylation down-regulates | 23431053 | SIGNOR-201129 |
| AKT3 | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20231902 | SIGNOR-164306 |
| AKT3 | UPF1 | Thr151 | FCNGRGNtSGSHIVN | phosphorylation up-regulates activity | 35675814 | SIGNOR-277596 |
| AKT3 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81118 |
| AKT3 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81122 |
| AKT3 | IWS1 | Ser720 | PQRRRMNsTGGQTPR | phosphorylation up-regulates activity | 24462114 | SIGNOR-273496 |
| AKT3 | IWS1 | Thr721 | QRRRMNStGGQTPRR | phosphorylation up-regulates activity | 24462114 | SIGNOR-273495 |
| AKT3 | AGO2 | Ser387 | SKLMRSAsFNTDPYV | phosphorylation up-regulates | 18476811 | SIGNOR-178416 |
| AKT3 | AGO2 | Ser387 | SKLMRSAsFNTDPYV | phosphorylation up-regulates | 23603119 | SIGNOR-201918 |
| AKT3 | IKK-complex | – | phosphorylation up-regulates | 19609947 | SIGNOR-217466 | |
| AKT3 | FOXO | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates | 19188143 | SIGNOR-252877 |
| AKT3 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates | 19188143 | SIGNOR-252878 |
| AKT3 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates | 19188143 | SIGNOR-252879 |
| AKT3 | FOXO | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252874 |
| AKT3 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252875 |
| AKT3 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252876 |
| AKT3 | STK3/4 | – | phosphorylation down-regulates | 20231902 | SIGNOR-269941 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT3 | phosphorylation up-regulates → | CHUK PThr23 | phosphorylation up-regulates → | CHUK | 19609947 | SIGNOR-187062 |
| AKT3 | phosphorylation up-regulates → | TBX3 PSer719 | phosphorylation up-regulates → | TBX3 | 25595898 | SIGNOR-223534 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183644 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183648 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183652 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249643 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249644 |
| AKT3 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249642 |
| AKT3 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186780 |
| AKT3 | phosphorylation up-regulates → | BRAF PSer364 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78693 |
| AKT3 | phosphorylation up-regulates → | BRAF PSer428 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78697 |
| AKT3 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-62257 |
| AKT3 | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251626 |
| AKT3 | phosphorylation up-regulates → | BMI1 PSer316 | phosphorylation up-regulates → | BMI1 | 22505453 | SIGNOR-249583 |
| AKT3 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23552696 | SIGNOR-245424 |
| AKT3 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 9812896 | SIGNOR-61565 |
| AKT3 | phosphorylation up-regulates → | ADAR PThr1033 | phosphorylation down-regulates ⊣ | ADAR | 31095429 | SIGNOR-276191 |
| AKT3 | phosphorylation up-regulates → | ADARB1 PThr553 | phosphorylation down-regulates ⊣ | ADARB1 | 31095429 | SIGNOR-276195 |
| AKT3 | phosphorylation up-regulates → | CYCS PTyr47 | phosphorylation down-regulates ⊣ | CYCS | 32781572 | SIGNOR-277235 |
| AKT3 | phosphorylation up-regulates → | POU5F1 PThr235 | phosphorylation up-regulates → | POU5F1 | 23041284 | SIGNOR-242107 |
| AKT3 | phosphorylation up-regulates → | STK4 PThr387 | phosphorylation down-regulates ⊣ | STK4 | 23431053 | SIGNOR-201129 |
| AKT3 | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20231902 | SIGNOR-164306 |
| AKT3 | phosphorylation up-regulates → | UPF1 PThr151 | phosphorylation up-regulates → | UPF1 | 35675814 | SIGNOR-277596 |
| AKT3 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81118 |
| AKT3 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81122 |
| AKT3 | phosphorylation up-regulates → | IWS1 PSer720 | phosphorylation up-regulates → | IWS1 | 24462114 | SIGNOR-273496 |
| AKT3 | phosphorylation up-regulates → | IWS1 PThr721 | phosphorylation up-regulates → | IWS1 | 24462114 | SIGNOR-273495 |
| AKT3 | phosphorylation up-regulates → | AGO2 PSer387 | phosphorylation up-regulates → | AGO2 | 18476811 | SIGNOR-178416 |
| AKT3 | phosphorylation up-regulates → | AGO2 PSer387 | phosphorylation up-regulates → | AGO2 | 23603119 | SIGNOR-201918 |
| AKT3 | phosphorylation up-regulates → | FOXO PSer253 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252877 |
| AKT3 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252878 |
| AKT3 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252879 |
| AKT3 | phosphorylation up-regulates → | FOXO PSer253 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252874 |
| AKT3 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252875 |
| AKT3 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252876 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT3 | phosphorylation → up-regulates | CHUK | SIGNOR-187062 |
| AKT3 | phosphorylation → up-regulates activity | TBX3 | SIGNOR-223534 |
| AKT3 | phosphorylation down-regulates | FOXO3 | SIGNOR-183644 |
| AKT3 | phosphorylation down-regulates | FOXO3 | SIGNOR-183648 |
| AKT3 | phosphorylation down-regulates | FOXO3 | SIGNOR-183652 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249643 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249644 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249642 |
| AKT3 | phosphorylation down-regulates | HSPB1 | SIGNOR-186780 |
| AKT3 | phosphorylation down-regulates | BRAF | SIGNOR-78693 |
| AKT3 | phosphorylation down-regulates | BRAF | SIGNOR-78697 |
| AKT3 | phosphorylation → up-regulates | CREB1 | SIGNOR-62257 |
| AKT3 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251626 |
| AKT3 | phosphorylation → up-regulates activity | BMI1 | SIGNOR-249583 |
| AKT3 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-245424 |
| AKT3 | phosphorylation down-regulates | CASP9 | SIGNOR-61565 |
| AKT3 | phosphorylation → down-regulates activity | ADAR | SIGNOR-276191 |
| AKT3 | phosphorylation → down-regulates activity | ADARB1 | SIGNOR-276195 |
| AKT3 | phosphorylation → down-regulates activity | CYCS | SIGNOR-277235 |
| AKT3 | phosphorylation → up-regulates quantity by stabilization | POU5F1 | SIGNOR-242107 |
| AKT3 | phosphorylation down-regulates | STK4 | SIGNOR-201129 |
| AKT3 | phosphorylation down-regulates | STK3 | SIGNOR-164306 |
| AKT3 | phosphorylation → up-regulates activity | UPF1 | SIGNOR-277596 |
| AKT3 | phosphorylation down-regulates | BAD | SIGNOR-81118 |
| AKT3 | phosphorylation down-regulates | BAD | SIGNOR-81122 |
| AKT3 | phosphorylation → up-regulates activity | IWS1 | SIGNOR-273496 |
| AKT3 | phosphorylation → up-regulates activity | IWS1 | SIGNOR-273495 |
| AKT3 | phosphorylation → up-regulates | AGO2 | SIGNOR-178416 |
| AKT3 | phosphorylation → up-regulates | AGO2 | SIGNOR-201918 |
| AKT3 | phosphorylation → up-regulates | IKK-complex | SIGNOR-217466 |
| AKT3 | phosphorylation down-regulates | FOXO | SIGNOR-252877 |
| AKT3 | phosphorylation down-regulates | FOXO | SIGNOR-252878 |
| AKT3 | phosphorylation down-regulates | FOXO | SIGNOR-252879 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252874 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252875 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252876 |
| AKT3 | phosphorylation down-regulates | STK3/4 | SIGNOR-269941 |