Summary

Name AKT3
Full Name RAC-gamma serine/threonine-protein kinase
Synonyms Protein kinase Akt-3, Protein kinase B gamma, PKB gamma, RAC-PK-gamma, STK-2 | PKBG
Primary ID Q9Y243
Links - -
Type protein
Relations 54
Inhibitors MK-2206; GSK690693
Function AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.2
Publications: 3
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.2
Publications: 3
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BMI1 0.14
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation BRAF 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AGO2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.14
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.42
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.2
Publications: 4 Organism: Homo Sapiens, Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation AKT3 0.34
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation, binding NOS3 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TBX3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STK3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHUK 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation POU5F1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT3 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ down-regulates img/direct_inhibition.png phosphorylation STK4 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png AKT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IKK-complex 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png AKT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT3 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT3 0.28
Publications: 1 Organism: Homo Sapiens