Summary

Name AKT3
Full Name RAC-gamma serine/threonine-protein kinase
Synonyms Protein kinase Akt-3, Protein kinase B gamma, PKB gamma, RAC-PK-gamma, STK-2 | PKBG
Primary ID Q9Y243
Links - -
Type protein
Relations 62
Inhibitors GSK690693; 3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]-4-piperidinyl]-1H-benzimidazol-2-one; MK-2206
Function AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.54
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.494
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.515
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.708
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.708
Publications: 3
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.708
Publications: 3
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.708
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BMI1 0.258
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation BRAF 0.29
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AGO2 0.424
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.737
Publications: 4 Organism: Homo Sapiens, Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.647
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.492
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.682
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT3 0.544
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation NOS3 0.482
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TBX3 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IWS1 0.382
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.286
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.736
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ADAR 0.2
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation STK3 0.271
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation UPF1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHUK 0.411
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation POU5F1 0.257
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT3 0.65
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ down-regulates img/direct_inhibition.png phosphorylation STK4 0.261
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ADARB1 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CYCS 0.265
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation STK3/4 0.271
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation JAG1 0.288
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AKT3 0.8
Publications: 1
+ down-regulates img/indirect_inhibition.png AKT3 0.249
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IKK-complex 0.416
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png AKT3 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT3 0.361
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT3 0.501
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation AKT3 0.8
Publications: 1 Organism: Homo Sapiens