| Name | AKT3 |
| ID | Q9Y243 |
| Role | substrate |
| Enzymatic Domains |
PH 5-107 PROSITE-ProRule
Protein kinase 148-405 PROSITE-ProRule
AGC-kinase C-terminal 406-479 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CB | AKT3 | Thr305 | TDAATMKtFCGTPEY | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248611 |
| PHLPP2 | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248731 |
| PPP2CA | AKT3 | Thr305 | TDAATMKtFCGTPEY | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248651 |
| PPP2CA | AKT3 | Thr305 | TDAATMKtFCGTPEY | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248654 |
| PRKCZ | AKT3 | Ser472 | RPHFPQFsYSASGRE | phosphorylation up-regulates activity | 12162751 | SIGNOR-249153 |
| PPP2CA | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248653 |
| PHLPP1 | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248330 |
| PRKCZ | AKT3 | Thr305 | TDAATMKtFCGTPEY | phosphorylation up-regulates activity | 9512493 | SIGNOR-248996 |
| PPP2CA | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248652 |
| ACP1 | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 17353188 | SIGNOR-248457 |
| PHLPP2 | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 17386267 | SIGNOR-237439 |
| PPP2CB | AKT3 | Thr309 | TMKTFCGtPEYLAPE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248612 |
| PPP2CB | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248610 |
| PDPK1 | AKT3 | Thr305 | TDAATMKtFCGTPEY | phosphorylation up-regulates | 9512493 | SIGNOR-55937 |
| PPP2CB | AKT3 | Ser474 | HFPQFSYsASGRE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248609 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CB | dephosphorylation down-regulates ⊣ | AKT3 PThr305 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248611 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 19261608 | SIGNOR-248731 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PThr305 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248651 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PThr305 | dephosphorylation up-regulates → | AKT3 | 15367694 | SIGNOR-248654 |
| PRKCZ | phosphorylation up-regulates → | AKT3 PSer472 | phosphorylation up-regulates → | AKT3 | 12162751 | SIGNOR-249153 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248653 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 19261608 | SIGNOR-248330 |
| PRKCZ | phosphorylation up-regulates → | AKT3 PThr305 | phosphorylation up-regulates → | AKT3 | 9512493 | SIGNOR-248996 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 15367694 | SIGNOR-248652 |
| ACP1 | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 17353188 | SIGNOR-248457 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 17386267 | SIGNOR-237439 |
| PPP2CB | dephosphorylation down-regulates ⊣ | AKT3 PThr309 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248612 |
| PPP2CB | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248610 |
| PDPK1 | phosphorylation up-regulates → | AKT3 PThr305 | phosphorylation up-regulates → | AKT3 | 9512493 | SIGNOR-55937 |
| PPP2CB | dephosphorylation down-regulates ⊣ | AKT3 PSer474 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248609 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CB | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248611 |
| PHLPP2 | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248731 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248651 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248654 |
| PRKCZ | phosphorylation → up-regulates activity | AKT3 | SIGNOR-249153 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248653 |
| PHLPP1 | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248330 |
| PRKCZ | phosphorylation → up-regulates activity | AKT3 | SIGNOR-248996 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248652 |
| ACP1 | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248457 |
| PHLPP2 | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-237439 |
| PPP2CB | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248612 |
| PPP2CB | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248610 |
| PDPK1 | phosphorylation → up-regulates | AKT3 | SIGNOR-55937 |
| PPP2CB | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248609 |