Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PHLPP1	AKT3	Ser472 View in OncoXplorer	RPHFPQFsYSASGRE	dephosphorylation down-regulates activity	19261608	SIGNOR-248330
PPP2CA	AKT3	Ser472 View in OncoXplorer	RPHFPQFsYSASGRE	dephosphorylation down-regulates activity	15367694	SIGNOR-248652
ACP1	AKT3	Ser472 View in OncoXplorer	RPHFPQFsYSASGRE	dephosphorylation down-regulates activity	17353188	SIGNOR-248457
PHLPP2	AKT3	Ser472 View in OncoXplorer	RPHFPQFsYSASGRE	dephosphorylation down-regulates activity	17386267	SIGNOR-237439
PPP2CB	AKT3	Ser472 View in OncoXplorer	RPHFPQFsYSASGRE	dephosphorylation down-regulates activity	18160256	SIGNOR-248610
PHLPP2	AKT3	Ser472 View in OncoXplorer	RPHFPQFsYSASGRE	dephosphorylation down-regulates activity	19261608	SIGNOR-248731
PRKCZ	AKT3	Ser472 View in OncoXplorer	RPHFPQFsYSASGRE	phosphorylation up-regulates activity	12162751	SIGNOR-249153
PPP2CA	AKT3	Ser472 View in OncoXplorer	RPHFPQFsYSASGRE	dephosphorylation down-regulates activity	18160256	SIGNOR-248653

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PHLPP1	dephosphorylation down-regulates ⊣	AKT3 PSer472	dephosphorylation up-regulates →	AKT3	19261608	SIGNOR-248330
PPP2CA	dephosphorylation down-regulates ⊣	AKT3 PSer472	dephosphorylation up-regulates →	AKT3	15367694	SIGNOR-248652
ACP1	dephosphorylation down-regulates ⊣	AKT3 PSer472	dephosphorylation up-regulates →	AKT3	17353188	SIGNOR-248457
PHLPP2	dephosphorylation down-regulates ⊣	AKT3 PSer472	dephosphorylation up-regulates →	AKT3	17386267	SIGNOR-237439
PPP2CB	dephosphorylation down-regulates ⊣	AKT3 PSer472	dephosphorylation up-regulates →	AKT3	18160256	SIGNOR-248610
PHLPP2	dephosphorylation down-regulates ⊣	AKT3 PSer472	dephosphorylation up-regulates →	AKT3	19261608	SIGNOR-248731
PRKCZ	phosphorylation up-regulates →	AKT3 PSer472	phosphorylation up-regulates →	AKT3	12162751	SIGNOR-249153
PPP2CA	dephosphorylation down-regulates ⊣	AKT3 PSer472	dephosphorylation up-regulates →	AKT3	18160256	SIGNOR-248653

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PHLPP1	dephosphorylation → down-regulates activity	AKT3	SIGNOR-248330
PPP2CA	dephosphorylation → down-regulates activity	AKT3	SIGNOR-248652
ACP1	dephosphorylation → down-regulates activity	AKT3	SIGNOR-248457
PHLPP2	dephosphorylation → down-regulates activity	AKT3	SIGNOR-237439
PPP2CB	dephosphorylation → down-regulates activity	AKT3	SIGNOR-248610
PHLPP2	dephosphorylation → down-regulates activity	AKT3	SIGNOR-248731
PRKCZ	phosphorylation → up-regulates activity	AKT3	SIGNOR-249153
PPP2CA	dephosphorylation → down-regulates activity	AKT3	SIGNOR-248653