| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | AKT3 | Ser472 | RPHFPQFsYSASGRE | phosphorylation up-regulates activity | 12162751 | SIGNOR-249153 |
| PPP2CA | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248653 |
| PHLPP1 | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248330 |
| PPP2CA | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248652 |
| ACP1 | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 17353188 | SIGNOR-248457 |
| PHLPP2 | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 17386267 | SIGNOR-237439 |
| PPP2CB | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248610 |
| PHLPP2 | AKT3 | Ser472 | RPHFPQFsYSASGRE | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248731 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | phosphorylation up-regulates → | AKT3 PSer472 | phosphorylation up-regulates → | AKT3 | 12162751 | SIGNOR-249153 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248653 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 19261608 | SIGNOR-248330 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 15367694 | SIGNOR-248652 |
| ACP1 | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 17353188 | SIGNOR-248457 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 17386267 | SIGNOR-237439 |
| PPP2CB | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248610 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT3 PSer472 | dephosphorylation up-regulates → | AKT3 | 19261608 | SIGNOR-248731 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCZ | phosphorylation → up-regulates activity | AKT3 | SIGNOR-249153 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248653 |
| PHLPP1 | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248330 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248652 |
| ACP1 | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248457 |
| PHLPP2 | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-237439 |
| PPP2CB | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248610 |
| PHLPP2 | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248731 |
