| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CB | AKT3 | Thr305 | TDAATMKtFCGTPEY | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248611 |
| PPP2CA | AKT3 | Thr305 | TDAATMKtFCGTPEY | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248651 |
| PPP2CA | AKT3 | Thr305 | TDAATMKtFCGTPEY | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248654 |
| PRKCZ | AKT3 | Thr305 | TDAATMKtFCGTPEY | phosphorylation up-regulates activity | 9512493 | SIGNOR-248996 |
| PDPK1 | AKT3 | Thr305 | TDAATMKtFCGTPEY | phosphorylation up-regulates | 9512493 | SIGNOR-55937 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CB | dephosphorylation down-regulates ⊣ | AKT3 PThr305 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248611 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PThr305 | dephosphorylation up-regulates → | AKT3 | 18160256 | SIGNOR-248651 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT3 PThr305 | dephosphorylation up-regulates → | AKT3 | 15367694 | SIGNOR-248654 |
| PRKCZ | phosphorylation up-regulates → | AKT3 PThr305 | phosphorylation up-regulates → | AKT3 | 9512493 | SIGNOR-248996 |
| PDPK1 | phosphorylation up-regulates → | AKT3 PThr305 | phosphorylation up-regulates → | AKT3 | 9512493 | SIGNOR-55937 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CB | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248611 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248651 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT3 | SIGNOR-248654 |
| PRKCZ | phosphorylation → up-regulates activity | AKT3 | SIGNOR-248996 |
| PDPK1 | phosphorylation → up-regulates | AKT3 | SIGNOR-55937 |
