| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAB1 | ULK1 | – | phosphorylation up-regulates | 21460634 | SIGNOR-173044 | |
| PRKAB1 | NOS3 | Ser1177 | TSRIRTQsFSLQERQ | phosphorylation up-regulates | 11729179 | SIGNOR-112367 |
| PRKAB1 | STIM1 | Ser257 | GLHRAEQsLHDLQER | phosphorylation down-regulates activity | 31381180 | SIGNOR-277298 |
| PRKAB1 | RPTOR | – | phosphorylation down-regulates | 21460634 | SIGNOR-173041 | |
| PRKAB1 | PROX1 | Ser79 | KLLKRANsYEDAMMP | phosphorylation down-regulates quantity by destabilization | 36433955 | SIGNOR-277609 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAB1 | phosphorylation up-regulates → | NOS3 PSer1177 | phosphorylation up-regulates → | NOS3 | 11729179 | SIGNOR-112367 |
| PRKAB1 | phosphorylation up-regulates → | STIM1 PSer257 | phosphorylation down-regulates ⊣ | STIM1 | 31381180 | SIGNOR-277298 |
| PRKAB1 | phosphorylation up-regulates → | PROX1 PSer79 | phosphorylation down-regulates ⊣ | PROX1 | 36433955 | SIGNOR-277609 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAB1 | phosphorylation → up-regulates | ULK1 | SIGNOR-173044 |
| PRKAB1 | phosphorylation → up-regulates | NOS3 | SIGNOR-112367 |
| PRKAB1 | phosphorylation → down-regulates activity | STIM1 | SIGNOR-277298 |
| PRKAB1 | phosphorylation down-regulates | RPTOR | SIGNOR-173041 |
| PRKAB1 | phosphorylation down-regulates quantity by destabilization | PROX1 | SIGNOR-277609 |
