| Name | IRS2 |
| ID | Q9Y4H2 |
| Role | substrate |
| Enzymatic Domains |
PH 16-144 PROSITE-ProRule
IRS-type PTB 194-298 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | IRS2 | Tyr628 | PKVAYHPyPEDYGDI | phosphorylation down-regulates activity | 9195949 | SIGNOR-251318 |
| INSR | IRS2 | Tyr632 | YHPYPEDyGDIEIGS | phosphorylation down-regulates activity | 9195949 | SIGNOR-251319 |
| IL4R | IRS2 | – | phosphorylation up-regulates | 12704343 | SIGNOR-100771 | |
| IGF1R | IRS2 | – | phosphorylation up-regulates | 10471495 | SIGNOR-70477 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | phosphorylation up-regulates → | IRS2 PTyr628 | phosphorylation down-regulates ⊣ | IRS2 | 9195949 | SIGNOR-251318 |
| INSR | phosphorylation up-regulates → | IRS2 PTyr632 | phosphorylation down-regulates ⊣ | IRS2 | 9195949 | SIGNOR-251319 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| INSR | phosphorylation → down-regulates activity | IRS2 | SIGNOR-251318 |
| INSR | phosphorylation → down-regulates activity | IRS2 | SIGNOR-251319 |
| IL4R | phosphorylation → up-regulates | IRS2 | SIGNOR-100771 |
| IGF1R | phosphorylation → up-regulates | IRS2 | SIGNOR-70477 |