| + |
INSR | down-regulates activity 
phosphorylation
|
IRS2 |
0.758 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251318 |
Tyr628 |
PKVAYHPyPEDYGDI |
in vitro |
|
| pmid |
sentence |
| 9195949 |
Tyr624 and Tyr628 are involved in the interaction between the IR and the KRLB domain of IRS-2, including tyrosine phosphorylation, and Tyr628 seems to be more important than Tyr624 in this process. the binding between the insulin receptor and the KRLB domain of IRS-2 results in tyrosine phosphorylation of the KRLB domain, and this leads to decreased binding of IRS-2 to the insulin receptor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251319 |
Tyr632 |
YHPYPEDyGDIEIGS |
in vitro |
|
| pmid |
sentence |
| 9195949 |
Tyr624 and Tyr628 are involved in the interaction between the IR and the KRLB domain of IRS-2, including tyrosine phosphorylation, and Tyr628 seems to be more important than Tyr624 in this process. the binding between the insulin receptor and the KRLB domain of IRS-2 results in tyrosine phosphorylation of the KRLB domain, and this leads to decreased binding of IRS-2 to the insulin receptor. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
APC-c | down-regulates quantity by destabilization
polyubiquitination
|
IRS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272196 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 32554797 |
We conducted an unbiased proteomic screen to uncover novel substrates of the Anaphase Promoting Complex/Cyclosome (APC/C), a ubiquitin ligase that controls the abundance of key cell cycle regulators. We found that IRS2 levels are regulated by APC/C activity and that IRS2 is a direct APC/C target in G1 Consistent with the APC/C's role in degrading cell cycle regulators. Consistent with this observation, we found that APC/C inhibition decreased the polyubiquitylation of HA-tagged IRS2 in HeLa cells treated with MG132 (Fig. 2G). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IGF1R | up-regulates 
phosphorylation
|
IRS2 |
0.802 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70477 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10471495 |
Our results reveal that igf-1 receptors promote beta-cell development and survival through the irs-2 signalling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma |
| + |
IRS2 | up-regulates
binding
|
PIK3CG |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103174 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12850284 |
There was a high level of irs-2 expression and insulin-stimulated tyrosyl phosphorylation as early as embryonic day 15 with robust pi3k binding and activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEDD4 | up-regulates activity
ubiquitination
|
IRS2 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278659 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25879670 |
Nedd4 monoubiquitinates IRS-2, which promotes its association with Epsin1, a ubiquitin binding protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL4R | up-regulates
phosphorylation
|
IRS2 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100771 |
|
|
Homo sapiens |
T-lymphocyte, Macrophage, Monocyte |
| pmid |
sentence |
| 12704343 |
Irs-1 and a homologous protein, irs-2 (also known as 4-phosphotyrosine substrate), are recruited to phosphorylated y497 of IL-4R After ligand binding, leading to phosphorylation and activation of irs-1 and irs-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Lung, Smooth Muscle |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
IRS2 |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278145 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 12842910 |
Taken together, these results indicate that the IRS2 gene is a direct target for CREB action in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRS2 | up-regulates activity
binding
|
PIK3CA |
0.686 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251492 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22810696 |
These results strongly suggest that the IGF2–IGF1R–IRS2 axis signals to PI3K in CRC and imply that therapeutic targeting of the pathway could act to block PI3K activity in this subset of patients. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma |
| + |
mTORC2 | up-regulates quantity by expression
transcriptional regulation
|
IRS2 |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278150 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 35065096 |
Additionally, PKA activates transducer of regulated CREB (TORC2) and cAMP response element-binding protein (CREB), which leads to beta cell proliferation through CREB- and TORC2-mediated IRS2 gene expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INSR | up-regulates
binding
|
IRS2 |
0.758 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253604 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 7629118 |
Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
IRS2 | up-regulates activity
binding
|
PI3K |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252696 |
|
|
Mus musculus |
Mammary Gland Tumor Cell |
| pmid |
sentence |
| 24811175 |
Insulin receptor substrate 1 (IRS-1) and IRS-2 are cytoplasmic adaptor proteins that mediate the activation of signaling pathways in response to ligand stimulation of upstream cell surface receptors. Despite sharing a high level of homology and the ability to activate PI3K, only Irs-2 positively regulates aerobic glycolysis in mammary tumor cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
IRS2
- 
- 