| Name | RIPK3 |
| ID | Q9Y572 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 21-287 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RIPK3 | DLD | Thr135 | STAVKALtGGIAHLF | phosphorylation up-regulates activity | 29358703 | SIGNOR-266372 |
| RIPK3 | TRIM28 | Ser473 | SGVKRSRsGEGEVSG | phosphorylation down-regulates activity | 34419074 | SIGNOR-279107 |
| RIPK3 | RIPK1 | – | phosphorylation up-regulates activity | 24535827 | SIGNOR-280106 | |
| RIPK3 | MLKL | Ser358 | ELRKTQTsMSLGTTR | phosphorylation up-regulates activity | 24012422 | SIGNOR-266439 |
| RIPK3 | MLKL | Ser358 | ELRKTQTsMSLGTTR | phosphorylation up-regulates activity | 24012422 | SIGNOR-266427 |
| RIPK3 | MLKL | Ser360 | RKTQTSMsLGTTREK | phosphorylation up-regulates activity | 24012422 | SIGNOR-266440 |
| RIPK3 | MLKL | Ser360 | RKTQTSMsLGTTREK | phosphorylation up-regulates activity | 24012422 | SIGNOR-266428 |
| RIPK3 | MLKL | Thr357 | FELRKTQtSMSLGTT | phosphorylation up-regulates activity | 24012422 | SIGNOR-266429 |
| RIPK3 | MLKL | Thr357 | FELRKTQtSMSLGTT | phosphorylation up-regulates activity | 24012422 | SIGNOR-266438 |
| RIPK3 | RIPK3 | Thr182 | GSGEPGGtLGYLAPE | phosphorylation up-regulates activity | 29883609 | SIGNOR-277396 |
| RIPK3 | OGDC | – | phosphorylation up-regulates activity | 29358703 | SIGNOR-268066 | |
| RIPK3 | PDH | – | phosphorylation up-regulates activity | 29358703 | SIGNOR-268065 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RIPK3 | phosphorylation up-regulates → | DLD PThr135 | phosphorylation up-regulates → | DLD | 29358703 | SIGNOR-266372 |
| RIPK3 | phosphorylation up-regulates → | TRIM28 PSer473 | phosphorylation down-regulates ⊣ | TRIM28 | 34419074 | SIGNOR-279107 |
| RIPK3 | phosphorylation up-regulates → | MLKL PSer358 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266439 |
| RIPK3 | phosphorylation up-regulates → | MLKL PSer358 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266427 |
| RIPK3 | phosphorylation up-regulates → | MLKL PSer360 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266440 |
| RIPK3 | phosphorylation up-regulates → | MLKL PSer360 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266428 |
| RIPK3 | phosphorylation up-regulates → | MLKL PThr357 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266429 |
| RIPK3 | phosphorylation up-regulates → | MLKL PThr357 | phosphorylation up-regulates → | MLKL | 24012422 | SIGNOR-266438 |
| RIPK3 | phosphorylation up-regulates → | RIPK3 PThr182 | phosphorylation up-regulates → | RIPK3 | 29883609 | SIGNOR-277396 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RIPK3 | phosphorylation → up-regulates activity | DLD | SIGNOR-266372 |
| RIPK3 | phosphorylation → down-regulates activity | TRIM28 | SIGNOR-279107 |
| RIPK3 | phosphorylation → up-regulates activity | RIPK1 | SIGNOR-280106 |
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266439 |
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266427 |
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266440 |
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266428 |
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266429 |
| RIPK3 | phosphorylation → up-regulates activity | MLKL | SIGNOR-266438 |
| RIPK3 | phosphorylation → up-regulates activity | RIPK3 | SIGNOR-277396 |
| RIPK3 | phosphorylation → up-regulates activity | OGDC | SIGNOR-268066 |
| RIPK3 | phosphorylation → up-regulates activity | PDH | SIGNOR-268065 |