Summary

Name RIPK3
Full Name Receptor-interacting serine/threonine-protein kinase 3
Synonyms RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3 | RIP3
Primary ID Q9Y572
Links - -
Type protein
Relations 15
Inhibitors ponatinib
Function Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation MLKL 0.738
Publications: 6 Organism: Mus Musculus, In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation DLD 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding RIPK3 0.619
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png chemical inhibition RIPK3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GLUD1 0.423
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png polyubiquitination RIPK3 0.662
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PDH 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png polyubiquitination RIPK3 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation OGDC 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding PYGL 0.502
Publications: 1 Organism: Homo Sapiens