| Name | DNMT3A |
| ID | Q9Y6K1 |
| Role | substrate |
| Enzymatic Domains |
PWWP 292-350 PROSITE-ProRule
ADD 482-614 PROSITE-ProRule
SAM-dependent MTase C5-type 634-912 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | DNMT3A | Ser393 | VCHDSDEsDTAKAVE | phosphorylation down-regulates activity | 25066127 | SIGNOR-276649 |
| PLK1 | DNMT3A | Ser393 | VCHDSDEsDTAKAVE | phosphorylation down-regulates activity | 34051063 | SIGNOR-279552 |
| CSNK2A1 | DNMT3A | Ser390 | LFPVCHDsDESDTAK | phosphorylation down-regulates activity | 25066127 | SIGNOR-276650 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | DNMT3A PSer393 | phosphorylation down-regulates ⊣ | DNMT3A | 25066127 | SIGNOR-276649 |
| PLK1 | phosphorylation up-regulates → | DNMT3A PSer393 | phosphorylation down-regulates ⊣ | DNMT3A | 34051063 | SIGNOR-279552 |
| CSNK2A1 | phosphorylation up-regulates → | DNMT3A PSer390 | phosphorylation down-regulates ⊣ | DNMT3A | 25066127 | SIGNOR-276650 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → down-regulates activity | DNMT3A | SIGNOR-276649 |
| PLK1 | phosphorylation → down-regulates activity | DNMT3A | SIGNOR-279552 |
| CSNK2A1 | phosphorylation → down-regulates activity | DNMT3A | SIGNOR-276650 |