Relation Results

Summary

Name DNMT3A
Full Name DNA
Synonyms Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA
Primary ID Q9Y6K1
Links - -
Type protein
Relations 20
Pathways Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, miRNA in AML, AML_TRIPLETS, Triple mutant AML
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is ...
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Type: Score: Layout: SPV 
0.20.2690.2930.7110.20.3280.20.7810.3380.20.70.3780.40.3790.3380.3260.5040.3470.2CSNK2A1DNMT3APLK1MECOMMYCFGF21MEIS1DPP6DNMT1/DNMT3ACDKN2CTIMP2DifferentiationCDKN2AmiR-29bWT1HOXA9STAT5ACCND1CDKN2BCDKN2D

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CSNK2A1down-regulates activity img/direct_inhibition.png phosphorylation DNMT3A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276650 Ser390 LFPVCHDsDESDTAK in vitro
pmid sentence
This modulation can be directly attributed to CK2-mediated phosphorylation of Dnmt3a. We also find that CK2-mediated phosphorylation is required for localization of Dnmt3a to heterochromatin.
Identifier Residue Sequence Organism Cell Line
SIGNOR-276649 Ser393 VCHDSDEsDTAKAVE in vitro
pmid sentence
This modulation can be directly attributed to CK2-mediated phosphorylation of Dnmt3a. We also find that CK2-mediated phosphorylation is required for localization of Dnmt3a to heterochromatin.
Publications: 2 Organism: In Vitro
+ PLK1down-regulates activity img/direct_inhibition.png phosphorylation DNMT3A 0.269
Identifier Residue Sequence Organism Cell Line
SIGNOR-279552 Ser393 VCHDSDEsDTAKAVE Homo sapiens
pmid sentence
2.11 Plk1 Directly Phosphorylates DNMT3a at S393.|Elevated Plk1 further inhibited DNMT3a via phosphorylation at S393 in mitosis in accord with its mitotic role during cell cycle.
Publications: 1 Organism: Homo Sapiens
+ MECOMup-regulates activity img/direct-activation.png binding DNMT3A 0.293
Identifier Residue Sequence Organism Cell Line
SIGNOR-273432
pmid sentence
The oncoprotein EVI1 and the DNA methyltransferase Dnmt3 co-operate in binding and de novo methylation of target DNA|Here we show that EVI1 physically interacts with DNA methyltransferases 3a and 3b (Dnmt3a/b), which are the only de novo DNA methyltransferases identified to date in mouse and man, and that it forms an enzymatically active protein complex that induces de novo DNA methylation in vitro.
Publications: 1
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML
+ MYCup-regulates activity img/direct-activation.png binding DNMT3A 0.711
Identifier Residue Sequence Organism Cell Line
SIGNOR-255806 Homo sapiens
pmid sentence
Based on one of these publications, we here showed that the interaction of Dnmt3a with c-myc promote the specific methylation of CG dinucleotides localized in c-myc boxes of promoter regions of CDKN2a, CCND1 and TIMP2 genes. Acellular experiments corroborated and complemented these results by revealing that the specificity of consensus sequence for DNA methylation of Dnmt3a is increased in presence of c-myc.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, miRNA in AML, AML_TRIPLETS, Triple mutant AML
+ DNMT3Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FGF21 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262200 Homo sapiens
pmid sentence
Unbiased gene profiling studies revealed Fgf21 as a key negatively regulated Dnmt3a target gene in adipocytes with concordant changes in DNA methylation at the Fgf21 promoter region.
Publications: 1 Organism: Homo Sapiens
+ DNMT3Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MEIS1 0.328
Identifier Residue Sequence Organism Cell Line
SIGNOR-256125 Homo sapiens
pmid sentence
Our results indicate that, in the absence of mixed lineage leukemia fusions, an alternative pathway for engaging an oncogenic MEIS1-dependent transcriptional program can be mediated by DNMT3A mutations.Under these circumstances, those AML patients carrying the alteration in the DNA methyltransferase would undergo a hypomethylation event at the MEIS1 promoter that would lead to the overexpression of this key oncogene in leukemia.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, AML_TRIPLETS, Triple mutant AML
+ DNMT3Adown-regulates quantity by repression img/direct_inhibition.png transcriptional regulation DPP6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268962 Mus musculus P-19 Cell
pmid sentence
In the absence of Dnmt3b, Dnmt3a was associated with Dpp6 gene promoter and regulated its expression and methylation in P19 cells.
Publications: 1 Organism: Mus Musculus
+ DNMT3Aform complex img/form-complex.png binding DNMT1/DNMT3A 0.781
Identifier Residue Sequence Organism Cell Line
SIGNOR-90842 Homo sapiens
pmid sentence
We show that the human de novo enzymes hdnmt3a and hdnmt3b form complexes with the major maintenance enzyme hdnmt1 /in vivo co-expression of hdnmt1 and hdnmt3a or hdnmt3b leads to methylation spreading in the genome, suggesting co-operation between de novo and maintenance enzymes during dna methylation
Publications: 1 Organism: Homo Sapiens
+ DNMT3Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN2C 0.338
Identifier Residue Sequence Organism Cell Line
SIGNOR-261508 Homo sapiens
pmid sentence
Quantitative real-time PCR (qPCR) was used to investigate the effect of DNMT3A on p18INK4C expression, along with the other INK4 members, including p15INK4B, p16INK4A and p19INK4D. The results showed that the depletion of DNMT3A increased the transcriptional levels of the four members of the INK4 family
Publications: 1 Organism: Homo Sapiens
+ DNMT3Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TIMP2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255807 Homo sapiens
pmid sentence
Based on one of these publications, we here showed that the interaction of Dnmt3a with c-myc promote the specific methylation of CG dinucleotides localized in c-myc boxes of promoter regions of CDKN2a, CCND1 and TIMP2 genes. Acellular experiments corroborated and complemented these results by revealing that the specificity of consensus sequence for DNA methylation of Dnmt3a is increased in presence of c-myc.
Publications: 1 Organism: Homo Sapiens
+ DNMT3Aup-regulates img/indirect-activation.png Differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255714 Homo sapiens
pmid sentence
The DNA methyltransferase 3 genes (DNMT3A and DNMT3B) encode methyltransferases that catalyze the addition of a methyl group to the cytosine residue of CpG dinucleotide; therefore they play an essential role in DNA methylation and gene silencing regulatory processes. DNMT3A function is involved in hematopoietic stem cells (HSCs) renewal and myeloid differentiation.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, miRNA in AML, AML_TRIPLETS, Triple mutant AML
+ DNMT3Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN2A 0.378
Identifier Residue Sequence Organism Cell Line
SIGNOR-255809 Homo sapiens
pmid sentence
Quantitative real-time PCR (qPCR) was used to investigate the effect of DNMT3A on p18INK4C expression, along with the other INK4 members, including p15INK4B, p16INK4A and p19INK4D. The results showed that the depletion of DNMT3A increased the transcriptional levels of the four members of the INK4 family
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, Triple mutant AML
+ miR-29bdown-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation DNMT3A 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-255927 Bos taurus
pmid sentence
Target prediction analysis revealed that ZNF423 was a potential target of bta-miR-23a. Dual-luciferase reporter assay revealed that bta-miR-23a directly targeted the 3′-UTR of ZNF423.
Publications: 1 Organism: Bos Taurus
+ WT1up-regulates quantity by expression img/direct-activation.png transcriptional regulation DNMT3A 0.379
Identifier Residue Sequence Organism Cell Line
SIGNOR-255904 Homo sapiens
pmid sentence
Here, we show that Wilms' tumour 1 (WT1), a developmental master regulator that can also act as a tumour suppressor or oncoprotein, transcriptionally regulates the de novo DNA methyltransferase 3A (DNMT3A) and that cellular WT1 levels can influence DNA methylation of gene promoters genome-wide. we demonstrate that depletion of WT1 by short-interfering RNAs leads to reduced DNMT3A in Wilms' tumour cells and human embryonal kidney-derived cell lines. Chromatin immunoprecipitation assays demonstrate WT1 recruitment to the DNMT3A promoter region and reporter assays confirm that WT1 directly transactivates DNMT3A expression.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, miRNA in AML
+ DNMT3Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HOXA9 0.338
Identifier Residue Sequence Organism Cell Line
SIGNOR-256128 Homo sapiens
pmid sentence
HOXA9 is significantly upregulated in both categories of DNMT3A modifications and this has been associated with poor prognosis in AML before (Figure 3d). In fact, almost the entire HOXA and HOXB cluster were significantly upregulated in AML samples with either epimutation or mutation in DNMT3A.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, AML_TRIPLETS, Triple mutant AML
+ STAT5Aup-regulates quantity img/direct-activation.png transcriptional regulation DNMT3A 0.326
Identifier Residue Sequence Organism Cell Line
SIGNOR-255631 Homo sapiens
pmid sentence
… these data suggest that STAT5A positively regulates levels of DNMT3A, resulting in inactivation of tumor suppressor genes by epigenetic mechanisms in AML cells
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, miRNA in AML, AML_TRIPLETS, Triple mutant AML
+ DNMT3Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CCND1 0.504
Identifier Residue Sequence Organism Cell Line
SIGNOR-255808 Homo sapiens
pmid sentence
Based on one of these publications, we here showed that the interaction of Dnmt3a with c-myc promote the specific methylation of CG dinucleotides localized in c-myc boxes of promoter regions of CDKN2a, CCND1 and TIMP2 genes. Acellular experiments corroborated and complemented these results by revealing that the specificity of consensus sequence for DNA methylation of Dnmt3a is increased in presence of c-myc.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, AML_TRIPLETS, Triple mutant AML
+ DNMT3Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN2B 0.347
Identifier Residue Sequence Organism Cell Line
SIGNOR-261509 Homo sapiens
pmid sentence
Quantitative real-time PCR (qPCR) was used to investigate the effect of DNMT3A on p18INK4C expression, along with the other INK4 members, including p15INK4B, p16INK4A and p19INK4D. The results showed that the depletion of DNMT3A increased the transcriptional levels of the four members of the INK4 family
Publications: 1 Organism: Homo Sapiens
+ DNMT3Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN2D 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261510 Homo sapiens
pmid sentence
Quantitative real-time PCR (qPCR) was used to investigate the effect of DNMT3A on p18INK4C expression, along with the other INK4 members, including p15INK4B, p16INK4A and p19INK4D. The results showed that the depletion of DNMT3A increased the transcriptional levels of the four members of the INK4 family
Publications: 1 Organism: Homo Sapiens
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