Summary

Name DNMT3A
Full Name DNA
Synonyms Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA
Primary ID Q9Y6K1
Links - -
Type protein
Relations 9
Pathways Acute Myeloid Leukemia, AML_miRNA, AML-DNMT3A
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation DNMT3A
Publications: 1 Organism: Homo Sapiens
Pathways:AML_miRNA
+ up-regulates activity img/direct-activation.png binding DNMT3A 0.09
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-DNMT3A, AML_miRNA
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression TIMP2 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression CCND1 0.05
Publications: 1 Organism: Homo Sapiens
Pathways:AML-DNMT3A
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression CDKN2A 0.12
Publications: 1 Organism: Homo Sapiens
Pathways:AML-DNMT3A
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation DNMT3A 0.07
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-DNMT3A, AML_miRNA
+ up-regulates quantity img/direct-activation.png transcriptional activation DNMT3A
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML_miRNA
+ form complex img/form-complex.png binding DNMT1/DNMT3A
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown Differentiation
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-DNMT3A, AML_miRNA