| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | IKBKG | Ser43 | PAMLHLPsEQGAPET | phosphorylation unknown | 12657630 | SIGNOR-251287 |
| PRKDC | IKBKG | Ser43 | PAMLHLPsEQGAPET | phosphorylation down-regulates activity | 31932854 | SIGNOR-277508 |
| ATM | IKBKG | Ser85 | ELLHFQAsQREEKEF | phosphorylation down-regulates activity | 16497931 | SIGNOR-144813 |
| IKK-complex | IKBKG | Ser85 | ELLHFQAsQREEKEF | phosphorylation down-regulates activity | 17977820 | SIGNOR-209784 |
| IKK-complex | IKBKG | Ser68 | LRDAIRQsNQILRER | phosphorylation down-regulates activity | 17977820 | SIGNOR-209788 |
| IKBKB | IKBKG | Ser85 | ELLHFQAsQREEKEF | phosphorylation down-regulates activity | 17977820 | SIGNOR-158663 |
| FGR | IKBKG | Tyr374 | PLPPAPAyLSSPLAL | phosphorylation down-regulates activity | 23131831 | SIGNOR-276368 |
| FYN | IKBKG | Tyr374 | PLPPAPAyLSSPLAL | phosphorylation down-regulates activity | 23131831 | SIGNOR-276371 |
| IKBKB | IKBKG | Ser31 | QDVLGEEsPLGKPAM | phosphorylation unknown | 12657630 | SIGNOR-251285 |
| IKK-complex | IKBKG | Ser43 | PAMLHLPsEQGAPET | phosphorylation unknown | 17977820 | SIGNOR-216403 |
| SRC | IKBKG | Tyr374 | PLPPAPAyLSSPLAL | phosphorylation down-regulates activity | 23131831 | SIGNOR-276370 |
| GSK3B | IKBKG | – | phosphorylation down-regulates quantity | 27929056 | SIGNOR-279527 | |
| IKBKB | IKBKG | Ser376 | PPAPAYLsSPLALPS | phosphorylation unknown | 12657630 | SIGNOR-251286 |
| IKBKB | IKBKG | Ser68 | LRDAIRQsNQILRER | phosphorylation down-regulates activity | 17977820 | SIGNOR-158659 |
| IKBKB | IKBKG | Ser43 | PAMLHLPsEQGAPET | phosphorylation unknown | 17977820 | SIGNOR-158655 |
| IKK-complex | IKBKG | Ser376 | PPAPAYLsSPLALPS | phosphorylation unknown | 12657630 | SIGNOR-209792 |
| LYN | IKBKG | Tyr374 | PLPPAPAyLSSPLAL | phosphorylation down-regulates activity | 23131831 | SIGNOR-276369 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | phosphorylation up-regulates → | IKBKG PSer43 | phosphorylation down-regulates ⊣ | IKBKG | 12657630 | SIGNOR-251287 |
| PRKDC | phosphorylation up-regulates → | IKBKG PSer43 | phosphorylation down-regulates ⊣ | IKBKG | 31932854 | SIGNOR-277508 |
| ATM | phosphorylation up-regulates → | IKBKG PSer85 | phosphorylation down-regulates ⊣ | IKBKG | 16497931 | SIGNOR-144813 |
| IKK-complex | phosphorylation up-regulates → | IKBKG PSer85 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-209784 |
| IKK-complex | phosphorylation up-regulates → | IKBKG PSer68 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-209788 |
| IKBKB | phosphorylation up-regulates → | IKBKG PSer85 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-158663 |
| FGR | phosphorylation up-regulates → | IKBKG PTyr374 | phosphorylation down-regulates ⊣ | IKBKG | 23131831 | SIGNOR-276368 |
| FYN | phosphorylation up-regulates → | IKBKG PTyr374 | phosphorylation down-regulates ⊣ | IKBKG | 23131831 | SIGNOR-276371 |
| IKBKB | phosphorylation up-regulates → | IKBKG PSer31 | phosphorylation down-regulates ⊣ | IKBKG | 12657630 | SIGNOR-251285 |
| IKK-complex | phosphorylation up-regulates → | IKBKG PSer43 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-216403 |
| SRC | phosphorylation up-regulates → | IKBKG PTyr374 | phosphorylation down-regulates ⊣ | IKBKG | 23131831 | SIGNOR-276370 |
| IKBKB | phosphorylation up-regulates → | IKBKG PSer376 | phosphorylation down-regulates ⊣ | IKBKG | 12657630 | SIGNOR-251286 |
| IKBKB | phosphorylation up-regulates → | IKBKG PSer68 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-158659 |
| IKBKB | phosphorylation up-regulates → | IKBKG PSer43 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-158655 |
| IKK-complex | phosphorylation up-regulates → | IKBKG PSer376 | phosphorylation down-regulates ⊣ | IKBKG | 12657630 | SIGNOR-209792 |
| LYN | phosphorylation up-regulates → | IKBKG PTyr374 | phosphorylation down-regulates ⊣ | IKBKG | 23131831 | SIGNOR-276369 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKB | phosphorylation → unknown | IKBKG | SIGNOR-251287 |
| PRKDC | phosphorylation → down-regulates activity | IKBKG | SIGNOR-277508 |
| ATM | phosphorylation → down-regulates activity | IKBKG | SIGNOR-144813 |
| IKK-complex | phosphorylation → down-regulates activity | IKBKG | SIGNOR-209784 |
| IKK-complex | phosphorylation → down-regulates activity | IKBKG | SIGNOR-209788 |
| IKBKB | phosphorylation → down-regulates activity | IKBKG | SIGNOR-158663 |
| FGR | phosphorylation → down-regulates activity | IKBKG | SIGNOR-276368 |
| FYN | phosphorylation → down-regulates activity | IKBKG | SIGNOR-276371 |
| IKBKB | phosphorylation → unknown | IKBKG | SIGNOR-251285 |
| IKK-complex | phosphorylation → unknown | IKBKG | SIGNOR-216403 |
| SRC | phosphorylation → down-regulates activity | IKBKG | SIGNOR-276370 |
| GSK3B | phosphorylation → down-regulates quantity | IKBKG | SIGNOR-279527 |
| IKBKB | phosphorylation → unknown | IKBKG | SIGNOR-251286 |
| IKBKB | phosphorylation → down-regulates activity | IKBKG | SIGNOR-158659 |
| IKBKB | phosphorylation → unknown | IKBKG | SIGNOR-158655 |
| IKK-complex | phosphorylation → unknown | IKBKG | SIGNOR-209792 |
| LYN | phosphorylation → down-regulates activity | IKBKG | SIGNOR-276369 |
