Summary

Name IKBKG
Full Name NF-kappa-B essential modulator
Synonyms NEMO, FIP-3, IkB kinase-associated protein 1, IKKAP1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, NF-kappa-B essential modifier | FIP3, NEMO
Primary ID Q9Y6K9
Links - -
Type protein
Relations 24
Pathways IL1 Receptor, Toll like receptors, NF-KB Canonical, Inhibition of Apoptosis
Function Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation IKBKG 1.00
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation IKBKG
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ down-regulates img/direct_inhibition.png phosphorylation IKBKG
Publications: 3 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ down-regulates activity img/direct_inhibition.png phosphorylation IKBKG 1.00
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IKBKG
Publications: 3 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation RELA 0.44
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation IKBKG 0.26
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NfKb-p65/p50
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ up-regulates activity img/direct-activation.png binding IKBKG 0.93
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ up-regulates activity img/direct-activation.png binding IKK-complex
Publications: 1 Organism: Mus Musculus
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ up-regulates activity img/direct-activation.png binding IKBKB 1.00
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IKBKG 0.75
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding IKBKG 0.89
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ up-regulates activity img/indirect-activation.png ubiquitination IKBKG 0.77
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IKK-complex
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor, Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors