| Name | CAK complex |
| ID | SIGNOR-C456 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAK complex | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation unknown | 9372954 | SIGNOR-269326 |
| CAK complex | TP53 | Ser371 | AHSSHLKsKKGQSTS | phosphorylation up-regulates | 9315650 | SIGNOR-269327 |
| CAK complex | TP53 | Ser376 | LKSKKGQsTSRHKKL | phosphorylation up-regulates | 9315650 | SIGNOR-269328 |
| CAK complex | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates | 9315650 | SIGNOR-269325 |
| CAK complex | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 9315650 | SIGNOR-269324 |
| CAK complex | CDK4 | Thr172 | YSYQMALtPVVVTLW | phosphorylation up-regulates | 8139570 | SIGNOR-269329 |
| CAK complex | RARG | Ser77 | SEEMVPSsPSPPPPP | phosphorylation up-regulates activity | 10748061 | SIGNOR-275969 |
| CAK complex | RARG | Ser79 | EMVPSSPsPPPPPRV | phosphorylation up-regulates activity | 10748061 | SIGNOR-275968 |
| CAK complex | CDK2 | Thr160 | GVPVRTYtHEVVTLW | phosphorylation up-regulates activity | 10085115 | SIGNOR-269330 |
| CAK complex | CDK12 | Thr893 | SEESRPYtNKVITLW | phosphorylation up-regulates activity | 24662513 | SIGNOR-275510 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAK complex | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation down-regulates ⊣ | TP53 | 9372954 | SIGNOR-269326 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer371 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-269327 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer376 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-269328 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-269325 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-269324 |
| CAK complex | phosphorylation up-regulates → | CDK4 PThr172 | phosphorylation up-regulates → | CDK4 | 8139570 | SIGNOR-269329 |
| CAK complex | phosphorylation up-regulates → | RARG PSer77 | phosphorylation up-regulates → | RARG | 10748061 | SIGNOR-275969 |
| CAK complex | phosphorylation up-regulates → | RARG PSer79 | phosphorylation up-regulates → | RARG | 10748061 | SIGNOR-275968 |
| CAK complex | phosphorylation up-regulates → | CDK2 PThr160 | phosphorylation up-regulates → | CDK2 | 10085115 | SIGNOR-269330 |
| CAK complex | phosphorylation up-regulates → | CDK12 PThr893 | phosphorylation up-regulates → | CDK12 | 24662513 | SIGNOR-275510 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAK complex | phosphorylation → unknown | TP53 | SIGNOR-269326 |
| CAK complex | phosphorylation → up-regulates | TP53 | SIGNOR-269327 |
| CAK complex | phosphorylation → up-regulates | TP53 | SIGNOR-269328 |
| CAK complex | phosphorylation → up-regulates | TP53 | SIGNOR-269325 |
| CAK complex | phosphorylation → up-regulates | TP53 | SIGNOR-269324 |
| CAK complex | phosphorylation → up-regulates | CDK4 | SIGNOR-269329 |
| CAK complex | phosphorylation → up-regulates activity | RARG | SIGNOR-275969 |
| CAK complex | phosphorylation → up-regulates activity | RARG | SIGNOR-275968 |
| CAK complex | phosphorylation → up-regulates activity | CDK2 | SIGNOR-269330 |
| CAK complex | phosphorylation → up-regulates activity | CDK12 | SIGNOR-275510 |