Relation Results

Summary

Name CAK complex
Primary ID SIGNOR-C456
Links CPX-578
Type complex
Formed by CCNH, CDK7, MNAT1
Relations 14

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Type: Score: Layout: SPV 
0.4370.4150.6240.5760.5360.8540.9610.9480.959CAK complexTP53RARGCDK2CDK4CDK12TFIIHCCNHMNAT1CDK7

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CAK complex img/unknown.png phosphorylation TP53 0.437
Identifier Residue Sequence Organism Cell Line
SIGNOR-269326 Ser33 LPENNVLsPLPSQAM Homo sapiens
pmid sentence
We have mapped a major site of phosphorylation by cak to ser-33 of p53 and have demonstrated as well that p53 is phosphorylated at this site in vivo.
Publications: 1 Organism: Homo Sapiens
+ CAK complexup-regulates img/direct-activation.png phosphorylation TP53 0.437
Identifier Residue Sequence Organism Cell Line
SIGNOR-269327 Ser371 AHSSHLKsKKGQSTS Homo sapiens
pmid sentence
The cdk7-cych-p36 complex of transcription factor iih phosphorylates p53, enhancing its sequence-specific dna binding activity in vitro.  serines 371, 376, 378, and 392 may be the potential sites for this kinase.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269328 Ser376 LKSKKGQsTSRHKKL Homo sapiens
pmid sentence
The cdk7-cych-p36 complex of transcription factor iih phosphorylates p53, enhancing its sequence-specific dna binding activity in vitro.  serines 371, 376, 378, and 392 may be the potential sites for this kinase.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269325 Ser378 SKKGQSTsRHKKLMF Homo sapiens
pmid sentence
The cdk7-cych-p36 complex of transcription factor iih phosphorylates p53, enhancing its sequence-specific dna binding activity in vitro.  serines 371, 376, 378, and 392 may be the potential sites for this kinase.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269324 Ser392 FKTEGPDsD Homo sapiens
pmid sentence
The cdk7-cych-p36 complex of transcription factor iih phosphorylates p53, enhancing its sequence-specific dna binding activity in vitro.  serines 371, 376, 378, and 392 may be the potential sites for this kinase.
Publications: 4 Organism: Homo Sapiens
+ CAK complexup-regulates activity img/direct-activation.png phosphorylation RARG 0.415
Identifier Residue Sequence Organism Cell Line
SIGNOR-275969 Ser77 SEEMVPSsPSPPPPP Chlorocebus aethiops COS-7 Cell
pmid sentence
Retinoic acid receptor gamma (RARgamma) is phosphorylated in COS-1 cells at two conserved serine residues located in the N-terminal region (serines 77 and 79 in RARgamma1 and serines 66 and 68 in RARgamma2) that contains the activation function AF-1. These serines are phosphorylated in vitro by cdk7, a cyclin-dependent kinase associated to cyclin H and MAT1 in the CAK complex (cdk7.cyclin H. MAT1), that is found either free or as a component of the transcription/DNA repair factor TFIIH. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-275968 Ser79 EMVPSSPsPPPPPRV Chlorocebus aethiops COS-7 Cell
pmid sentence
Retinoic acid receptor gamma (RARgamma) is phosphorylated in COS-1 cells at two conserved serine residues located in the N-terminal region (serines 77 and 79 in RARgamma1 and serines 66 and 68 in RARgamma2) that contains the activation function AF-1. These serines are phosphorylated in vitro by cdk7, a cyclin-dependent kinase associated to cyclin H and MAT1 in the CAK complex (cdk7.cyclin H. MAT1), that is found either free or as a component of the transcription/DNA repair factor TFIIH. 
Publications: 2 Organism: Chlorocebus Aethiops
+ CAK complexup-regulates activity img/direct-activation.png phosphorylation CDK2 0.624
Identifier Residue Sequence Organism Cell Line
SIGNOR-269330 Thr160 GVPVRTYtHEVVTLW in vitro
pmid sentence
Phosphorylation of monomeric human CDK2 by CAK1 is more efficient than phosphorylation of the binary CDK2-cyclin A complex. Phosphorylated CDK2 exhibits histone H1 kinase activity corresponding to approximately 0.3% of that observed with the fully activated phosphorylated CDK2-cyclin A complex. Fluorescence measurements have shown that Thr160 phosphorylation increases the affinity of CDK2 for both histone substrate and ATP and decreases its affinity for ADP.
Publications: 1 Organism: In Vitro
+ CAK complexup-regulates img/direct-activation.png phosphorylation CDK4 0.576
Identifier Residue Sequence Organism Cell Line
SIGNOR-269329 Thr172 YSYQMALtPVVVTLW Homo sapiens
pmid sentence
Phosphorylation of cdk4 on threonine 172 by a cdk-activating kinase (cak).  therefore, formation of the cyclin d-cdk4 complex and phosphorylation of the bound catalytic subunit are independently regulated, and in addition to the requirement for cak activity, serum stimulation is required to promote assembly of the complexes in mammalian cells.
Publications: 1 Organism: Homo Sapiens
+ CAK complexup-regulates activity img/direct-activation.png phosphorylation CDK12 0.536
Identifier Residue Sequence Organism Cell Line
SIGNOR-275510 Thr893 SEESRPYtNKVITLW
pmid sentence
Although Cdk12/CycK kinase complex lacking T-loop phosphorylation showed some basal activity towards a CTD substrate prephosphorylated at position Ser7, its activity was significantly increased upon coexpression with the CAK from S. cerevisiae (Supplementary Fig. 9a). Mutation of T893 to E to mimic phosphorylation showed no effect on basal kinase activity. Quantitative phosphorylation of a single residue occurred upon coexpression with Cak1, as determined by ESI mass spectrometry (Supplementary Fig. 9b).
Publications: 1
+ CAK complexform complex img/form-complex.png binding TFIIH 0.854
Identifier Residue Sequence Organism Cell Line
SIGNOR-269318 Homo sapiens
pmid sentence
Transcription factor IIH (TFIIH) is a heterodecameric protein complex critical for transcription initiation by RNA polymerase II and nucleotide excision DNA repair.|The TFIIH core complex is composed of the seven subunits XPB, XPD, p62, p52, p44, p34, and p8, and is the form of TFIIH active in DNA repair|and additionally the CdK activating kinase (CAK) complex, which harbors the kinase activity of CDK7 as well as the Cyclin H and MAT1 subunits
Publications: 1 Organism: Homo Sapiens
+ CCNHform complex img/form-complex.png binding CAK complex 0.961
Identifier Residue Sequence Organism Cell Line
SIGNOR-269321 Homo sapiens
pmid sentence
CdK activating kinase (CAK) complex, which harbors the kinase activity of CDK7 as well as the Cyclin H and MAT1 subunits
Publications: 1 Organism: Homo Sapiens
+ MNAT1form complex img/form-complex.png binding CAK complex 0.948
Identifier Residue Sequence Organism Cell Line
SIGNOR-269320 Homo sapiens
pmid sentence
CdK activating kinase (CAK) complex, which harbors the kinase activity of CDK7 as well as the Cyclin H and MAT1 subunits
Publications: 1 Organism: Homo Sapiens
+ CDK7form complex img/form-complex.png binding CAK complex 0.959
Identifier Residue Sequence Organism Cell Line
SIGNOR-269319 Homo sapiens
pmid sentence
CdK activating kinase (CAK) complex, which harbors the kinase activity of CDK7 as well as the Cyclin H and MAT1 subunits
Publications: 1 Organism: Homo Sapiens
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