| Name | AKT1_Thr32 |
| ID | SIGNOR-PF27 |
| Role | residue |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 11154281 | SIGNOR-252988 |
| AKT | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-252825 |
| AKT2 | FOXO | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates activity | 11313479 | SIGNOR-252873 |
| PPP2CA | FOXO | Thr32 | QSRPRSCtWPLQRPE | dephosphorylation up-regulates | 20110348 | SIGNOR-252974 |
| PIM1 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates | 18593906 | SIGNOR-252967 |
| AKT1 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-252848 |
| AKT | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252823 |
| AKT2 | FOXO | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates activity | 16272144 | SIGNOR-252870 |
| AKT1 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252846 |
| AKT3 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252876 |
| SGK2 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 11154281 | SIGNOR-252991 |
| AKT3 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates | 19188143 | SIGNOR-252879 |
| AKT2 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-252869 |
| AKT | FOXO | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates | 16272144 | SIGNOR-252830 |
| AKT1 | FOXO | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates | 16272144 | SIGNOR-252855 |
| AKT2 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252865 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 11154281 | SIGNOR-252988 |
| AKT | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252825 |
| AKT2 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 11313479 | SIGNOR-252873 |
| PPP2CA | dephosphorylation down-regulates ⊣ | FOXO PThr32 | dephosphorylation down-regulates ⊣ | FOXO | 20110348 | SIGNOR-252974 |
| PIM1 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 18593906 | SIGNOR-252967 |
| AKT1 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252848 |
| AKT | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252823 |
| AKT2 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 16272144 | SIGNOR-252870 |
| AKT1 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252846 |
| AKT3 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252876 |
| SGK2 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 11154281 | SIGNOR-252991 |
| AKT3 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252879 |
| AKT2 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252869 |
| AKT | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 16272144 | SIGNOR-252830 |
| AKT1 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 16272144 | SIGNOR-252855 |
| AKT2 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252865 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SGK1 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252988 |
| AKT | phosphorylation → down-regulates activity | FOXO | SIGNOR-252825 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252873 |
| PPP2CA | dephosphorylation → up-regulates | FOXO | SIGNOR-252974 |
| PIM1 | phosphorylation down-regulates | FOXO | SIGNOR-252967 |
| AKT1 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252848 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252823 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252870 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252846 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252876 |
| SGK2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252991 |
| AKT3 | phosphorylation down-regulates | FOXO | SIGNOR-252879 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252869 |
| AKT | phosphorylation down-regulates | FOXO | SIGNOR-252830 |
| AKT1 | phosphorylation down-regulates | FOXO | SIGNOR-252855 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252865 |