| + |
AKT | down-regulates activity 
phosphorylation
|
FOXO |
0.909 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252838 |
Ser197 |
APRRRAAsMDSSSKL |
Mus musculus |
NIH-3T3-A14 Cell |
| pmid |
sentence |
| 10217147 |
Here we show that protein kinase B phosphorylates AFX, a human orthologue of daf -16 (refs 5, 6, 9), both in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252826 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252839 |
Ser262 |
TFRPRSSsNASSVST |
Mus musculus |
|
| pmid |
sentence |
| 10217147 |
Here we show that protein kinase B phosphorylates AFX, a human orthologue of daf -16 (refs 5, 6, 9), both in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252827 |
Ser315 |
DFRSRTNsNASTVSG |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252825 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252836 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 18423396 |
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export of FoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation |
|
| Publications: |
6 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling, Thyroid Hormone Metabolism |
| + |
AKT1 | down-regulates activity
phosphorylation
|
FOXO |
0.909 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252861 |
Ser197 |
APRRRAAsMDSSSKL |
Mus musculus |
NIH-3T3-A14 Cell |
| pmid |
sentence |
| 10217147 |
Here we show that protein kinase B phosphorylates AFX, a human orthologue of daf -16 (refs 5, 6, 9), both in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252849 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252862 |
Ser262 |
TFRPRSSsNASSVST |
Mus musculus |
|
| pmid |
sentence |
| 10217147 |
Here we show that protein kinase B phosphorylates AFX, a human orthologue of daf -16 (refs 5, 6, 9), both in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252850 |
Ser315 |
DFRSRTNsNASTVSG |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252848 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252851 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 18423396 |
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export ofFoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252841 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Akt inactivates protein degradation by phosphorylating and thus repressing the transcription factors of the foxo family, and stimulates protein synthesis via the mammalian target of rapamycin (mtor) and glycogen synthase kinase 3b (gsk3b). |
|
| Publications: |
7 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | FLT3-ITD signaling |
| + |
AKT1 | down-regulates
phosphorylation, relocalization
|
FOXO |
0.909 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252853 |
Ser197 |
APRRRAAsMDSSSKL |
Homo sapiens |
|
| pmid |
sentence |
| 16272144 |
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252856 |
Ser256 |
SPRRRAAsMDNNSKF |
in vitro |
CV-1 Cell |
| pmid |
sentence |
| 10377430 |
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252854 |
Ser262 |
TFRPRSSsNASSVST |
Homo sapiens |
|
| pmid |
sentence |
| 16272144 |
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252860 |
Ser319 |
TFRPRTSsNASTISG |
Homo sapiens |
|
| pmid |
sentence |
| 11237865 |
The transcription factor, forkhead in rhabdomyosarcoma (fkhr), is phosphorylated at three amino acid residues (thr-24, ser-256 and ser-319) by protein kinase b (pkb)alpha.Fkhr (forkhead in rhabdomyosarcoma), afx (all1 fused gene from chromosome x) and fkhrl1 (fkhr-like 1) are phosphorylated directly by pkb in cells, preventing them from stimulating gene transcription and leading to their exit from the nucleus |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252857 |
Thr24 |
LPRPRSCtWPLPRPE |
in vitro |
CV-1 Cell |
| pmid |
sentence |
| 10377430 |
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252855 |
Thr32 |
QSRPRSCtWPLPRPE |
Homo sapiens |
|
| pmid |
sentence |
| 16272144 |
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
The phosphorylation of the two remaining akt-dependent sites inhibits foxo6 transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252847 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21620960 |
Akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. In addition, phosphorylation of afx by protein kinase b inhibits its transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Akt inactivates protein degradation by phosphorylating and thus repressing the transcription factors of the foxo family, and stimulates protein synthesis via the mammalian target of rapamycin (mtor) and glycogen synthase kinase 3b (gsk3b). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252852 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 18423396 |
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export ofFoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation. |
|
| Publications: |
10 |
Organism: |
Homo Sapiens, In Vitro, Mus Musculus |
| Pathways: | FLT3-ITD signaling |
| + |
AKT | down-regulates
phosphorylation, relocalization
|
FOXO |
0.909 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252828 |
Ser197 |
APRRRAAsMDSSSKL |
Homo sapiens |
|
| pmid |
sentence |
| 16272144 |
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252831 |
Ser256 |
SPRRRAAsMDNNSKF |
in vitro |
CV-1 Cell |
| pmid |
sentence |
| 10377430 |
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252829 |
Ser262 |
TFRPRSSsNASSVST |
Homo sapiens |
|
| pmid |
sentence |
| 16272144 |
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252835 |
Ser319 |
TFRPRTSsNASTISG |
Homo sapiens |
|
| pmid |
sentence |
| 11237865 |
The transcription factor, forkhead in rhabdomyosarcoma (fkhr), is phosphorylated at three amino acid residues (thr-24, ser-256 and ser-319) by protein kinase b (pkb)alpha.Fkhr (forkhead in rhabdomyosarcoma), afx (all1 fused gene from chromosome x) and fkhrl1 (fkhr-like 1) are phosphorylated directly by pkb in cells, preventing them from stimulating gene transcription and leading to their exit from the nucleus |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252832 |
Thr24 |
LPRPRSCtWPLPRPE |
in vitro |
CV-1 Cell |
| pmid |
sentence |
| 10377430 |
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252830 |
Thr32 |
QSRPRSCtWPLPRPE |
Homo sapiens |
|
| pmid |
sentence |
| 16272144 |
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252824 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21620960 |
Akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. In addition, phosphorylation of afx by protein kinase b inhibits its transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252820 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Akt inactivates protein degradation by phosphorylating and thus repressing the transcription factors of the foxo family, and stimulates protein synthesis via the mammalian target of rapamycin (mtor) and glycogen synthase kinase 3b (gsk3b). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252834 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
The phosphorylation of the two remaining akt-dependent sites inhibits foxo6 transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252837 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 18423396 |
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export of FoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation |
|
| Publications: |
10 |
Organism: |
Homo Sapiens, In Vitro, Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling, Thyroid Hormone Metabolism |
| + |
STK4 | up-regulates 
phosphorylation
|
FOXO |
0.676 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253001 |
Ser209 |
SSAGWKNsIRHNLSL |
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253000 |
Ser209 |
SSAGWKNsIRHNLSL |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22898666 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252998 |
Ser212 |
SSAGWKNsIRHNLSL |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22898666 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252999 |
Ser212 |
SSAGWKNsIRHNLSL |
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253002 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1 |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| + |
JNK | up-regulates
phosphorylation
|
FOXO |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252953 |
Ser230 |
PEGATPTsPVGHFAK |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252954 |
Thr227 |
PAPPEGAtPTSPVGH |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252955 |
Thr451 |
PIPKALGtPVLTPPT |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252956 |
Thr455 |
ALGTPVLtPPTEAAS |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | FLT3-ITD signaling |
| + |
CDK2 | down-regulates
phosphorylation
|
FOXO |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252892 |
Ser249 |
EGGKSGKsPRRRAAS |
Homo sapiens |
|
| pmid |
sentence |
| 17038621 |
Cdk2 specifically phosphorylated foxo1 at serine-249 (ser249) in vitro and in vivo. Phosphorylation of ser249 resulted in cytoplasmic localization and inhibition of foxo1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252891 |
|
|
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK1 | down-regulates
phosphorylation
|
FOXO |
0.52 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252890 |
Ser249 |
EGGKSGKsPRRRAAS |
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 18408765 |
Overexpression of cdk1 inhibits the transcriptional activity of foxo1 in pca cells through s249 phosphorylation on foxo1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML |
| + |
PPP2CA | up-regulates
dephosphorylation
|
FOXO |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252973 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 20110348 |
Protein phosphatase 2a reactivates foxo3a through a dynamic interplay with 14-3-3 and aktpp2a-mediated dephosphorylation of t32/s253 is required for dissociation of 14-3-3, nuclear translocation, and transcriptional activation of foxo3a. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252971 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
Pp2a-mediated dephosphorylation of t32/s253 is required for dissociation of 14-3-3, nuclear translocation, and transcriptional activation of foxo3a. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252974 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 20110348 |
Protein phosphatase 2a reactivates foxo3a through a dynamic interplay with 14-3-3 and aktpp2a-mediated dephosphorylation of t32/s253 is required for dissociation of 14-3-3, nuclear translocation, and transcriptional activation of foxo3a. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | PI3K/AKT Signaling |
| + |
SGK2 | down-regulates activity
phosphorylation
|
FOXO |
0.518 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252990 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11154281 |
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252991 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11154281 |
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PIM1 | down-regulates
phosphorylation
|
FOXO |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252966 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
Pim-mediated phosphorylation and inactivation of forkhead transcription factors, foxo1a and foxo3a, was involved in the transcriptional repression of the p27(kip1) gene. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252967 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
Pim1s expression induced the phosphorylation of foxo3a (fig. 5a and b) and inactivated its transcriptional activity (fig. 5c). A previous report showed that phosphorylation at t32, s253, and s315 residues in foxo3a induced 14-3-3 binding, nuclear export, and proteasomemediated degradation (42). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling |
| + |
SGK3 | down-regulates activity
phosphorylation
|
FOXO |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252992 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11154281 |
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT2 | down-regulates activity
phosphorylation
|
FOXO |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252867 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252871 |
Ser256 |
SPRRRAAsMDNNSKF |
Homo sapiens |
|
| pmid |
sentence |
| 10377430 |
Our results demonstrate that pkb/akt directly phosphorylates fkhr1, a member of the closely related fkhr subclass of the forkhead family of transcription factors, on at least two residues (threonine-24 and serine-253). These results indicate that phosphorylation by pkbyakt negatively regulates fkhr1 by promoting export from the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252868 |
Ser315 |
DFRSRTNsNASTVSG |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252872 |
Thr24 |
LPRPRSCtWPLPRPE |
Homo sapiens |
|
| pmid |
sentence |
| 10377430 |
Our results demonstrate that pkb/akt directly phosphorylates fkhr1, a member of the closely related fkhr subclass of the forkhead family of transcription factors, on at least two residues (threonine-24 and serine-253). These results indicate that phosphorylation by pkbyakt negatively regulates fkhr1 by promoting export from the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252873 |
Thr32 |
QSRPRSCtWPLPRPE |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 11313479 |
Phosphorylation of AFX by PKB occurs in the nucleus. Phosphorylation of S193 reduces the rate of nuclear import. PKB-mediated phosphorylation of AFX, therefore, attenuates the import of the transcription factor, which shifts the localization of the protein from the nucleus to the cytoplasm and results in the inhibition of AFX transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252869 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252870 |
Thr32 |
QSRPRSCtWPLPRPE |
Homo sapiens |
|
| pmid |
sentence |
| 16272144 |
FOXO4 transcription factor, also referred to AFX, contains three putative phosphorylation motif sites for protein kinase B (PKB), Thr32, Ser197, and Ser262, and it is proposed that phosphorylated FOXO4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression.[...]These results indicate that phosphorylation at Thr32 and Ser197 is indispensable, whereas that at Ser262 is not critical, for regulation of the nuclear localization and transcriptional activity of FOXO4 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252866 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21620960 |
Akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. In addition, phosphorylation of afx by protein kinase b inhibits its transcriptional activity. |
|
| Publications: |
8 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
AKT3 | down-regulates
phosphorylation
|
FOXO |
0.702 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252877 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252878 |
Ser315 |
DFRSRTNsNASTVSG |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252879 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SGK1 | down-regulates activity
phosphorylation
|
FOXO |
0.79 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252987 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11154281 |
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252989 |
Ser315 |
DFRSRTNsNASTVSG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11154281 |
We show here that sgk1, like akt, promotes cell survival and that it does so in part by phosphorylating and inactivating fkhrl1. However, sgk and akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on fkhrl1. While both kinases can phosphorylate thr-32, sgk displays a marked preference for ser-315 whereas akt favors ser-253. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252988 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11154281 |
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
AKT | down-regulates quantity by destabilization
phosphorylation
|
FOXO |
0.909 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252821 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252822 |
Ser315 |
DFRSRTNsNASTVSG |
Homo sapiens |
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252823 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252833 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21440011 |
Phosphorylation of FoxOs by Akt inhibits transcriptional functions of FoxOs and contributes to cell survival, growth and proliferation.The PI3K/Akt signaling regulates cell proliferation and survival in part by phosphorylating FoxOs to promote their interaction with 14-3-3 protein that results in nuclear exclusion and eventual ubiquitin proteasome pathway (UPP)-dependent degradation of FoxOs |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling, Thyroid Hormone Metabolism |
| + |
AKT3 | down-regulates quantity by destabilization
phosphorylation
|
FOXO |
0.702 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252874 |
Ser253 |
APRRRAVsMDNSNKY |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252875 |
Ser315 |
DFRSRTNsNASTVSG |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252876 |
Thr32 |
QSRPRSCtWPLQRPE |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Publications: |
3 |
| + |
AKT1 | down-regulates quantity by destabilization
phosphorylation
|
FOXO |
0.909 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252844 |
Ser253 |
APRRRAVsMDNSNKY |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252845 |
Ser315 |
DFRSRTNsNASTVSG |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252846 |
Thr32 |
QSRPRSCtWPLQRPE |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252858 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21440011 |
Phosphorylation of FoxOs by Akt inhibits transcriptional functions of FoxOs and contributes to cell survival, growth and proliferation.The PI3K/Akt signaling regulates cell proliferation and survival in part by phosphorylating FoxOs to promote their interaction with 14-3-3 protein that results in nuclear exclusion and eventual ubiquitin proteasome pathway (UPP)-dependent degradation of FoxOs |
|
| Publications: |
4 |
Organism: |
, Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
AKT2 | down-regulates quantity by destabilization
phosphorylation
|
FOXO |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252863 |
Ser253 |
APRRRAVsMDNSNKY |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252864 |
Ser315 |
DFRSRTNsNASTVSG |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252865 |
Thr32 |
QSRPRSCtWPLQRPE |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Publications: |
3 |
| + |
PKN1 | down-regulates
phosphorylation
|
FOXO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252968 |
Ser256 |
SPRRRAAsMDNNSKF |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 12560069 |
Furthermore, estrogen induced phosphorylation and perinuclear localization of the cell survival forkhead transcription factor fkhr in the cytoplasm in a pak1-dependent manner. In addition, pak1 directly interacted with fkhr and phosphorylated it. The noticed phosphorylation-dependent exclusion of fkhr from the nucleus impaired the ability of fkhr to activate its target fas ligand promoter containing the fkhr binding motif (fre) in cells treated with estrogen or expressing catalytically active pak1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates quantity by destabilization
phosphorylation
|
FOXO |
0.588 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252961 |
Ser294 |
QLSKWPGsPTSRSSD |
Homo sapiens |
|
| pmid |
sentence |
| 19282669 |
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252962 |
Ser344 |
QDDDAPLsPMLYSSS |
Homo sapiens |
|
| pmid |
sentence |
| 19282669 |
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252963 |
Ser425 |
TKGSGLGsPTSSFNS |
Homo sapiens |
|
| pmid |
sentence |
| 19282669 |
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | down-regulates quantity by destabilization
phosphorylation
|
FOXO |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252957 |
Ser294 |
QLSKWPGsPTSRSSD |
Homo sapiens |
|
| pmid |
sentence |
| 18204439 |
Here, we show that erk downregulates forkhead box o 3a (foxo3a) by directly interacting with and phosphorylating foxo3a at ser 294, ser 344 and ser 425, which consequently promotes cell proliferation and tumorigenesisMDM2 is required for ERk-mediated FOXO3a degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252958 |
Ser344 |
QDDDAPLsPMLYSSS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18204439 |
Here, we show that erk downregulates forkhead box o 3a (foxo3a) by directly interacting with and phosphorylating foxo3a at ser 294, ser 344 and ser 425, which consequently promotes cell proliferation and tumorigenesisMDM2 is required for ERk-mediated FOXO3a degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252959 |
Ser425 |
TKGSGLGsPTSSFNS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18204439 |
Here, we show that erk downregulates forkhead box o 3a (foxo3a) by directly interacting with and phosphorylating foxo3a at ser 294, ser 344 and ser 425, which consequently promotes cell proliferation and tumorigenesisMDM2 is required for ERk-mediated FOXO3a degradation. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1 | down-regulates
phosphorylation
|
FOXO |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252899 |
Ser318 |
SRTNSNAsTVSGRLS |
Homo sapiens |
|
| pmid |
sentence |
| 20110348 |
Casein kinase (ck) 1 mediates the hierarchical phosphorylation of foxo3a at s318 and s321, which like foxo1 (rena et al., 2002 blue right-pointing triangle, 2004 blue right-pointing triangle), is probably to enhance its rate of nuclear export |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252900 |
Ser321 |
NSNASTVsGRLSPIM |
Homo sapiens |
|
| pmid |
sentence |
| 20110348 |
Casein kinase (ck) 1 mediates the hierarchical phosphorylation of foxo3a at s318 and s321, which like foxo1 (rena et al., 2002 blue right-pointing triangle, 2004 blue right-pointing triangle), is probably to enhance its rate of nuclear export |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252898 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CSNK1G1 | down-regulates activity
phosphorylation
|
FOXO |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252901 |
Ser322 |
PRTSSNAsTISGRLS |
in vitro |
|
| pmid |
sentence |
| 11980723 |
Phosphorylation of Ser319 forms a consensus sequence for phosphorylation by CK1, allowing it to phosphorylate Ser322, which in turn primes the CK1-catalysed phosphorylation of Ser325 | Multisite phosphorylation of the region containing Ser319, Ser322, Ser325 and Ser329 provides a signal for the nuclear exclusion of FKHR |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252902 |
Ser325 |
SSNASTIsGRLSPIM |
in vitro |
|
| pmid |
sentence |
| 11980723 |
Phosphorylation of Ser319 forms a consensus sequence for phosphorylation by CK1, allowing it to phosphorylate Ser322, which in turn primes the CK1-catalysed phosphorylation of Ser325 | Multisite phosphorylation of the region containing Ser319, Ser322, Ser325 and Ser329 provides a signal for the nuclear exclusion of FKHR |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
DYRK1A | down-regulates activity
phosphorylation
|
FOXO |
0.516 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252909 |
Ser329 |
STISGRLsPIMTEQD |
Homo sapiens |
|
| pmid |
sentence |
| 11311120 |
The kinase dyrk1a phosphorylates the transcription factor fkhr at ser329 in vitro, a novel in vivo phosphorylation siteser(329) phosphorylation also decreases the ability of fkhr to stimulate gene transactivation and reduces the proportion of fkhr present in the nucleus |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252906 |
Ser330 |
RLSPIMAsTELDEVQ |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity phosphorylation of foxos by akt, ikk, erk, ck1, cdk2, and dyrk1a universally leads to foxo's inhibition. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DYRK1A | down-regulates
phosphorylation
|
FOXO |
0.516 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252907 |
Ser330 |
RLSPIMAsTELDEVQ |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity phosphorylation of foxos by akt, ikk, erk, ck1, cdk2, and dyrk1a universally leads to foxo's inhibition. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252905 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AMPK | up-regulates activity
phosphorylation
|
FOXO |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252880 |
Ser399 |
DNITLPPsQPSPTGG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252881 |
Ser413 |
GLMQRSSsFPYTTKG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252882 |
Ser555 |
RALSNSVsNMGLSES |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252883 |
Ser588 |
QTLSDSLsGSSLYST |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252884 |
Ser626 |
SLECDMEsIIRSELM |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252885 |
Thr179 |
SSPDKRLtLSQIYEW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252889 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17900900 |
The energy sensor amp-activated protein kinase (ampk) has been shown to directly phosphorylate foxo factors at six regulatory sites that are distinct from the akt. |
|
| Publications: |
7 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML, FLT3-ITD signaling, NPM1_new |
| + |
PRKAA1 | up-regulates activity
phosphorylation
|
FOXO |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252975 |
Ser399 |
DNITLPPsQPSPTGG |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252976 |
Ser413 |
GLMQRSSsFPYTTKG |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252977 |
Ser555 |
RALSNSVsNMGLSES |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252978 |
Ser588 |
QTLSDSLsGSSLYST |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252979 |
Ser626 |
SLECDMEsIIRSELM |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252980 |
Thr179 |
SSPDKRLtLSQIYEW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252983 |
|
|
Caenorhabditis elegans |
|
| pmid |
sentence |
| 17900900 |
The energy sensor amp-activated protein kinase (ampk) has been shown to directly phosphorylate foxo factors at six regulatory sites that are distinct from the akt. |
|
| Publications: |
7 |
Organism: |
Homo Sapiens, Caenorhabditis Elegans |
| + |
CHUK | down-regulates
phosphorylation
|
FOXO |
0.56 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252893 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15084260 |
Ikappab kinase promotes tumorigenesis through inhibition of forkhead foxo3a. The tnf treatment of ht-29 cells increased ikk-dependent foxo3 ser644 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKK-complex | down-regulates quantity by destabilization
phosphorylation
|
FOXO |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252951 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
IKBKB | down-regulates
phosphorylation
|
FOXO |
0.683 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252948 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15084260 |
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252947 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
IKBKE | down-regulates
phosphorylation
|
FOXO |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252949 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
Breast Cancer Cell, Lung Cancer Cell |
| pmid |
sentence |
| 23691078 |
Ikbke phosphorylation and inhibition of foxo3a: a mechanism of ikbke oncogenic functionhere we report that ikbke regulates foxo3a through phosphorylation of foxo3a-ser644. The phosphorylation of foxo3a resulted in its degradation and nuclear-cytoplasmic translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKK-complex | down-regulates
phosphorylation
|
FOXO |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252950 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15084260 |
Ikappab kinase promotes tumorigenesis through inhibition of forkhead foxo3a. The tnf treatment of ht-29 cells increased ikk-dependent foxo3 ser644 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
FOXO |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252960 |
Ser7 |
sPAPLSPL |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 22128155 |
Ogether, our results suggest that p38 phosphorylation of foxo3a on ser-7 is essential for its nuclear relocalization in response to doxorubicin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
RALA | up-regulates activity
phosphorylation
|
FOXO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252984 |
Thr451 |
PIPKALGtPVLTPPT |
Mus musculus |
|
| pmid |
sentence |
| 11689711 |
We conclude that Ral-mediated phosphorylation of threonines 447 and 451 is required for proper activity of AFX-WT. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252985 |
Thr455 |
ALGTPVLtPPTEAAS |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 11689711 |
We conclude that Ral-mediated phosphorylation of threonines 447 and 451 is required for proper activity of AFX-WT. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
MAPK8 | up-regulates
phosphorylation
|
FOXO |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252964 |
Thr451 |
PIPKALGtPVLTPPT |
Homo sapiens |
|
| pmid |
sentence |
| 15538382 |
Upon treatment of cells with h2o2, the small gtpase ral is activated and this results in a jnk-dependent phosphorylation of foxo4 on threonine 447 and threonine 451. This ral-mediated, jnk-dependent phosphorylation is involved in the nuclear translocation and transcriptional activation of foxo4 after h2o2 treatment. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252965 |
Thr455 |
ALGTPVLtPPTEAAS |
Homo sapiens |
|
| pmid |
sentence |
| 15538382 |
Upon treatment of cells with h2o2, the small gtpase ral is activated and this results in a jnk-dependent phosphorylation of foxo4 on threonine 447 and threonine 451. This ral-mediated, jnk-dependent phosphorylation is involved in the nuclear translocation and transcriptional activation of foxo4 after h2o2 treatment. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
FOXO | up-regulates quantity by expression 
transcriptional regulation
|
G6PC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252923 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252920 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252921 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252922 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18805788 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates
|
Metabolism |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253016 |
|
|
|
|
| pmid |
sentence |
| 18391974 |
Forkhead proteins, and FoxO1 in particular, play a significant role in regulating whole body energy metabolism. |
|
| Publications: |
1 |
| + |
FOXO | down-regulates quantity by repression 
transcriptional regulation
|
GK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252919 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18805788 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription foxo1 localizes to the nucleus, where it represses hnf-4-dependent activity of the gk promoter as a corepressor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | down-regulates quantity
transcriptional regulation
|
NOTCH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254306 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24749067 |
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
14-3-3 | down-regulates
binding
|
FOXO |
0.706 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252819 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 1010227 |
Progressive increase in akt activation during prostate cancer progression led to increase phosphorylation of foxo3a and binding with 14-3-3, which potentially affected its transcriptional activity in age-specific manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252818 |
|
|
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
In this study, we demonstrate that akt also regulates the activity of fkhrl1, a member of the forkhead family of transcription factors. In the presence of survival factors, akt phosphorylates fkhrl1, leading to fkhrl1's association with 14-3-3 proteins and fkhrl1's retention in the cytoplasm. Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FOXO | down-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252938 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, IDH-TET in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling |
| + |
AMPK | up-regulates
phosphorylation
|
FOXO |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252886 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17900900 |
The energy sensor amp-activated protein kinase (ampk) has been shown to directly phosphorylate foxo factors at six regulatory sites that are distinct from the akt phosphorylation sites, resulting in foxo activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML, FLT3-ITD signaling, NPM1_new |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
FBXO32 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254991 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18612045 |
These findings present new insights into the role of the GR and FOXO family of transcription factors in the transcriptional regulation of the MuRF1 gene, a direct target of the GR in skeletal muscle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252926 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 15109499 |
The activity of the PI3K/AKT pathway decreases, leading to activation of Foxo transcription factors and atrogin-1 induction. IGF-1 treatment or AKT overexpression inhibits Foxo and atrogin-1 expression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252929 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15109499 |
Constitutively active Foxo3 acts on the atrogin-1 promoter to cause atrogin-1 transcription and dramatic atrophy of myotubes and muscle fibers |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| + |
SIRT1 | down-regulates quantity by destabilization
binding
|
FOXO |
0.91 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252996 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24003218 |
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
PPARGC1A | down-regulates
|
FOXO |
0.573 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252970 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19491292 |
Nuclear pgc-1alpha and foxo3a respond in a reciprocal manner following aicar treatment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
BCL2L11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252914 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12913110 |
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates quantity
transcriptional regulation
|
RBL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252934 |
|
|
Homo sapiens |
NIH-3T3 Cell |
| pmid |
sentence |
| 11884591 |
Here we show that the Forkheads AFX (FOXO4) and FKHR-L1 (FOXO3a) also directly control transcription of the retinoblastoma-like p130 protein and cause upregulation of p130 protein expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TEAD1 | up-regulates quantity by expression
transcriptional regulation
|
FOXO |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253003 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21211055 |
Tead1 can regulate transcription of the foxo3a gene through the binding to the m-cat element, demonstrated with independent chip-pcr analysis, emsa and luciferase reporter system assay. The over-expression and inhibition analysis suggest that foxo3a was positively regulated by tead1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC1 | up-regulates activity
deacetylation
|
FOXO |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256485 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24463822 |
Through the use of various pharmacological inhibitors to block HDAC activity, we demonstrate that class I HDACs are key regulators of FoxO and the muscle-atrophy program during both nutrient deprivation and skeletal muscle disuse. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle |
| + |
FOXO | down-regulates quantity
transcriptional regulation
|
NOTCH3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252941 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24749067 |
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
FBXO32 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252945 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
TRIM63 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252927 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 18612045 |
Transcriptional reporter assays performed in both HepG2 and C2C12 cells demonstrate that the MuRF1 promoter is highly responsive to dexamethasone-activated glucocorticoid receptor (GR) and FoxO1 individually, while co-overexpression of GR and FoxO1 leads to a dramatic synergistic increase in reporter activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252946 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
Muscle |
| + |
FOXO | up-regulates activity
transcriptional regulation
|
TRIM63 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254990 |
|
|
Mus musculus |
|
| pmid |
sentence |
| PMC3619734 |
Here, we show that in cultured myotubes undergoing atrophy, the activity of the PI3K/AKT pathway decreases, leading to activation of Foxo transcription factors and atrogin-1induction. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
PCK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252924 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
MYOD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252937 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 18854138 |
Our cell-based assays and in vitro studies reveal a tight codependent partnership between foxo3 and pax3/7 to coordinately recruit rna polymerase ii and form a preinitiation complex (pic) to activate myod transcription in myoblasts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates
deacetylation
|
FOXO |
0.91 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252993 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15126506 |
Deacetylation of foxos involves binding of the nad-dependent deacetylase hsir2(sirt1). Accordingly, hsir2(sirt1)-mediated deacetylation precludes foxo inhibition through acetylation and thereby prolongs foxo-dependent transcription of stress-regulating genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
CDKN2B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252917 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17873901 |
Foxo1a strongly activated p15ink4b transcription and p19ink4d transcription, while foxo3a showed higher p19ink4d transcription activity than p15ink4b transcription activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TSC22D3 | down-regulates activity
relocalization
|
FOXO |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269854 |
|
|
Homo sapiens |
HL-60 Cell |
| pmid |
sentence |
| 20018851 |
GILZ inhibits FOXO1, FOXO3, and FOXO4 transcriptional activities measured with natural or synthetic FOXO-responsive promoters in HL-60 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | up-regulates
phosphorylation
|
FOXO |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252981 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17900900 |
The energy sensor amp-activated protein kinase (ampk) has been shown to directly phosphorylate foxo factors at six regulatory sites that are distinct from the akt phosphorylation sites, resulting in foxo activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260088 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML, NPM1_new |
| + |
FOXO | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256644 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252939 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new |
| + |
FOXO | down-regulates
|
PPARGC1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252915 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Foxo1 antagonized ppargamma activity and vice versa indicating that these transcription factors functionally interact in a reciprocal antagonistic manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252916 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Foxo1 antagonized ppargamma activity and vice versa indicating that these transcription factors functionally interact in a reciprocal antagonistic manner. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Gbeta | down-regulates quantity by destabilization
phosphorylation
|
FOXO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270020 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19282669 |
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
IGFBP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252925 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10358076 |
Reporter gene studies in hepg2 hepatoma cells show that fkhr stimulates insulin-like growth factor-binding protein-1 promoter activity through an irs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
CITED2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252933 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 18158893 |
Foxo3a induces expression of cited2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates activity
|
FOXO |
0.91 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252995 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
PPARGC1A | down-regulates quantity by repression
transcriptional regulation
|
FOXO |
0.573 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252969 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20404331 |
Capacity of PGC-1alpha and PGC-1beta to inhibit FoxO3 and NFkappaB actions and proteolysis helps explain how exercise prevents muscle atrophy.overexpression of PGC-1_ inhibits muscle wasting induced by denervation, starvation, and even caFoxO3 expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
SIRT1 | up-regulates activity
deacetylation
|
FOXO |
0.91 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252994 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
SIRT1 | down-regulates
|
FOXO |
0.91 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252997 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24003218 |
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
FOXO | down-regulates quantity
transcriptional regulation
|
NOTCH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252940 |
|
|
Mus musculus |
Satellite Cell |
| pmid |
sentence |
| 24749067 |
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling |
| + |
INS | down-regulates activity
|
FOXO |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252952 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10358076 |
Insulin disrupts irs-dependent transactivation by fkhr, and phosphorylation of ser-256 by pkb is necessary and sufficient to mediate this effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
G6P |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270252 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates quantity
transcriptional regulation
|
CDKN1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252928 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10783894 |
AFX transcriptionally activates p27kip1, resulting in increased protein levels. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML |
| + |
SETD2 | up-regulates quantity by expression
transcriptional regulation
|
FOXO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252986 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 18158893 |
In response to hypoxia, foxo3a transcript levels accumulate in an hif1-dependent way, resulting in enhanced foxo3a activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252932 |
|
|
Mus musculus |
Skeletal Muscle |
| pmid |
sentence |
| 15109499 |
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
CDKN2D |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252918 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17873901 |
Foxo1a strongly activated p15ink4b transcription and p19ink4d transcription, while foxo3a showed higher p19ink4d transcription activity than p15ink4b transcription activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | down-regulates activity
binding
|
FOXO |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252894 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15126506 |
We provide evidence that the acetyltransferase creb-binding protein (cbp) binds foxo resulting in acetylation of foxo. This acetylation inhibits foxo transcriptional activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, PI3K/AKT Signaling, Thyroid Hormone Metabolism |
| + |
DUSP6 | up-regulates
dephosphorylation
|
FOXO |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252903 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252911 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18423396 |
Akt1/pkbalpha was found to be the major regulator of phosphorylation and nuclear export offoxo1, whose presence in the nucleus strongly attenuates adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
PIM | down-regulates
phosphorylation
|
FOXO |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259427 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
Pim-mediated phosphorylation and inactivation of forkhead transcription factors, foxo1a and foxo3a, was involved in the transcriptional repression of the p27(kip1) gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML |
| + |
FOXO | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252910 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 16670091 |
FOXO1 coexpression dose-dependently repressed transcription from either the PPARgamma 1 or PPARgamma2 promoter reporter by 65%, whereas insulin (100 nm, 20-24 h) either partially or completely reversed this effect. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ERK1/2 | down-regulates quantity by destabilization
phosphorylation
|
FOXO |
0.714 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270146 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19282669 |
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
FASLG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252942 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10102273 |
Within the nucleus, fkhrl1 triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the fas ligand gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FOXO