| Name | AKT_Ser315 |
| ID | SIGNOR-PF27 |
| Role | residue |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-252850 |
| SGK1 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 11154281 | SIGNOR-252989 |
| AKT | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-252827 |
| AKT3 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252875 |
| AKT2 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-252868 |
| AKT2 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252864 |
| AKT | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252822 |
| AKT1 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252845 |
| AKT3 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates | 19188143 | SIGNOR-252878 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252850 |
| SGK1 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 11154281 | SIGNOR-252989 |
| AKT | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252827 |
| AKT3 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252875 |
| AKT2 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252868 |
| AKT2 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252864 |
| AKT | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252822 |
| AKT1 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252845 |
| AKT3 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252878 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252850 |
| SGK1 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252989 |
| AKT | phosphorylation → down-regulates activity | FOXO | SIGNOR-252827 |
| AKT3 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252875 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252868 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252864 |
| AKT | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252822 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252845 |
| AKT3 | phosphorylation down-regulates | FOXO | SIGNOR-252878 |