Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PIM1	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates	18593906	SIGNOR-252966
SGK2	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates activity	11154281	SIGNOR-252990
AKT1	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates quantity by destabilization	19951971	SIGNOR-252844
SGK3	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates activity	11154281	SIGNOR-252992
AKT2	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates quantity by destabilization	19951971	SIGNOR-252863
AKT3	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates quantity by destabilization	19951971	SIGNOR-252874
PPP2CA	FOXO	Ser253	APRRRAVsMDNSNKY	dephosphorylation up-regulates	20110348	SIGNOR-252973
SGK1	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates activity	11154281	SIGNOR-252987
AKT	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates activity	19188143	SIGNOR-252826
PPP2CA	FOXO	Ser253	APRRRAVsMDNSNKY	dephosphorylation up-regulates	18593906	SIGNOR-252971
AKT2	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates activity	19188143	SIGNOR-252867
AKT1	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates activity	19188143	SIGNOR-252849
AKT	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates quantity by destabilization	19951971	SIGNOR-252821
AKT3	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates	19188143	SIGNOR-252877

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PIM1	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	18593906	SIGNOR-252966
SGK2	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	11154281	SIGNOR-252990
AKT1	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	19951971	SIGNOR-252844
SGK3	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	11154281	SIGNOR-252992
AKT2	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	19951971	SIGNOR-252863
AKT3	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	19951971	SIGNOR-252874
PPP2CA	dephosphorylation down-regulates ⊣	FOXO PSer253	dephosphorylation down-regulates ⊣	FOXO	20110348	SIGNOR-252973
SGK1	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	11154281	SIGNOR-252987
AKT	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	19188143	SIGNOR-252826
PPP2CA	dephosphorylation down-regulates ⊣	FOXO PSer253	dephosphorylation down-regulates ⊣	FOXO	18593906	SIGNOR-252971
AKT2	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	19188143	SIGNOR-252867
AKT1	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	19188143	SIGNOR-252849
AKT	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	19951971	SIGNOR-252821
AKT3	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	19188143	SIGNOR-252877

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PIM1	phosphorylation down-regulates	FOXO	SIGNOR-252966
SGK2	phosphorylation → down-regulates activity	FOXO	SIGNOR-252990
AKT1	phosphorylation down-regulates quantity by destabilization	FOXO	SIGNOR-252844
SGK3	phosphorylation → down-regulates activity	FOXO	SIGNOR-252992
AKT2	phosphorylation down-regulates quantity by destabilization	FOXO	SIGNOR-252863
AKT3	phosphorylation down-regulates quantity by destabilization	FOXO	SIGNOR-252874
PPP2CA	dephosphorylation → up-regulates	FOXO	SIGNOR-252973
SGK1	phosphorylation → down-regulates activity	FOXO	SIGNOR-252987
AKT	phosphorylation → down-regulates activity	FOXO	SIGNOR-252826
PPP2CA	dephosphorylation → up-regulates	FOXO	SIGNOR-252971
AKT2	phosphorylation → down-regulates activity	FOXO	SIGNOR-252867
AKT1	phosphorylation → down-regulates activity	FOXO	SIGNOR-252849
AKT	phosphorylation down-regulates quantity by destabilization	FOXO	SIGNOR-252821
AKT3	phosphorylation down-regulates	FOXO	SIGNOR-252877