Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
JNK	FOXO	Thr227	PAPPEGAtPTSPVGH	phosphorylation up-regulates	20959475	SIGNOR-252954

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
JNK	phosphorylation up-regulates →	FOXO PThr227	phosphorylation up-regulates →	FOXO	20959475	SIGNOR-252954

Regulator	Mechanism/Effect	Target	SIGNOR-ID
JNK	phosphorylation → up-regulates	FOXO	SIGNOR-252954