Entity Details

Name LATS1/2
ID SIGNOR-PF43
Role kinase
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
LATS1/2YAP1Ser127PQHVRAHsSPASLQLphosphorylation
down-regulates activity		22658639SIGNOR-256188
LATS1/2YAP1Ser397TYHSRDEsTDSGLSMphosphorylation
down-regulates quantity by destabilization		20048001SIGNOR-277636
LATS1/2WWTR1Ser89AQHVRSHsSPASLQLphosphorylation
down-regulates activity		22658639SIGNOR-256187
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
LATS1/2phosphorylation
up-regulates
→
YAP1
PSer127		phosphorylation
down-regulates
⊣		YAP122658639SIGNOR-256188
LATS1/2phosphorylation
up-regulates
→
YAP1
PSer397		phosphorylation
down-regulates
⊣		YAP120048001SIGNOR-277636
LATS1/2phosphorylation
up-regulates
→
WWTR1
PSer89		phosphorylation
down-regulates
⊣		WWTR122658639SIGNOR-256187
Regulator Mechanism/Effect Target SIGNOR-ID
LATS1/2phosphorylation
→
down-regulates activity 		YAP1SIGNOR-256188
LATS1/2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		YAP1SIGNOR-277636
LATS1/2phosphorylation
→
down-regulates activity 		WWTR1SIGNOR-256187