| + |
LATS1/2 | down-regulates activity 
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256188 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
LATS1/2 | down-regulates quantity by destabilization
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277636 |
Ser397 |
TYHSRDEsTDSGLSM |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20048001 |
We show that YAP is phosphorylated by Lats on Ser 381 in one of the HXRXXS motifs, and this phosphorylation provides the priming signal for CK1delta/epsilon to phosphorylate a phosphodegron in YAP. The phosphorylated phosphodegron recruits beta-TRCP, leading to YAP ubiquitination and degradation under conditions of elevated Hippo pathway activity, such as cell contact inhibition |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
LATS1/2 | down-regulates activity
phosphorylation
|
WWTR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256187 |
Ser89 |
AQHVRSHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
sphingosine 1-phosphate | down-regulates 
|
LATS1/2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269864 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | up-regulates 
phosphorylation
|
LATS1/2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269863 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 23644383 |
Here, we show that cyclic amp (camp)-dependent protein kinase (pka) phosphorylates lats and thereby enhances its activity sufficiently to phosphorylate yap on ser381. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Mob1 | up-regulates activity
binding
|
LATS1/2 |
0.941 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256186 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling |
| + |
STK3 | up-regulates
phosphorylation
|
LATS1/2 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269862 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
lysophosphatidic acids | down-regulates
|
LATS1/2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269868 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MOB1A | up-regulates
binding
|
LATS1/2 |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269866 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
MOB1B | up-regulates
binding
|
LATS1/2 |
0.918 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269865 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
NF2 | up-regulates activity
binding
|
LATS1/2 |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33058421 |
The Hippo pathway tumor suppressor Merlin/NF2 is known to be regulated by phosphorylation. Here, the E3 ubiquitin ligase NEDD4L is shown to promote Hippo pathway activation via ubiquitination of Merlin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK4 | up-regulates
phosphorylation
|
LATS1/2 |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
VEPH1 | down-regulates quantity by repression
transcriptional regulation
|
LATS1/2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269858 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22055343 |
Melted represses warts transcription to disrupt hippo pathway activity and specify rh5 fate wts and melt repress each other s transcription in a double negative, bistable feedback loop that directs robust expression of either rh5 or rh6 in r9 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LATS1/2 | down-regulates quantity by repression
transcriptional regulation
|
VEPH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269959 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22055343 |
Melted represses warts transcription to disrupt hippo pathway activity and specify rh5 fate wts and melt repress each other s transcription in a double negative, bistable feedback loop that directs robust expression of either rh5 or rh6 in r9 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWC1 | up-regulates activity
binding
|
LATS1/2 |
0.782 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263659 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21233212 |
Here, we show that KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif. KIBRA overexpression stimulates the phosphorylation of Yes-associated protein (YAP), the Hippo pathway effector. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
GCG | up-regulates 
|
LATS1/2 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269857 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | down-regulates activity
phosphorylation
|
LATS1/2 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30889378 |
SRC can directly phosphorylate and inhibit LATS |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Integrin Signaling |
| + |
F2R | down-regulates
|
LATS1/2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269860 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22972936 |
Par1 acts through g12/13 and rho gtpase to inhibit the lats1/2 kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F-actin_assembly | down-regulates
|
LATS1/2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23450633 |
Ga12/13 recruitment of rho-gefs causes rhoa activation and f-actin assembly, which promotes lats1/lat2 inactivation by an unknown, but myosin-independent mechanism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
(R)-adrenaline | up-regulates
|
LATS1/2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269867 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LATS1/2