3.0
FAP: BMP
Pathway ID: SIGNOR-FapBMPView in NDEx
Description: Recent findings support the hypothesis that Fibro/Adipogenic Progenitors (FAPs) are the cell population responsible for Heterotopic Ossification (HO) in skeletal muscle. FAPs are able to differentiate into osteoblasts when stimulated with Bone Morphogenetic Proteins (BMPs). These cytokines bind Type I and Type II serine/threonine receptors that transduce signal into the cell. SMAD-dependent pathway and SMAD-independent pathway (a MAPK signal transduction) up-regulate osteogenic transcription factors, such as RUNX2, DLX5 and SP7, starting osteoblast differentiation.
Curated by: Marco Rosina
Description: Recent findings support the hypothesis that Fibro/Adipogenic Progenitors (FAPs) are the cell population responsible for Heterotopic Ossification (HO) in skeletal muscle. FAPs are able to differentiate into osteoblasts when stimulated with Bone Morphogenetic Proteins (BMPs). These cytokines bind Type I and Type II serine/threonine receptors that transduce signal into the cell. SMAD-dependent pathway and SMAD-independent pathway (a MAPK signal transduction) up-regulate osteogenic transcription factors, such as RUNX2, DLX5 and SP7, starting osteoblast differentiation.
Curated by: Marco Rosina
