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orthology-mapped

orthology-mapped
SIGNOR is a repository of manually annotated causal relationships between human proteins, chemicals of biological relevance, stimuli and phenotypes. The search field below allows users to access the entity page detailing all the causal relationships annotated to the query entity. SIGNOR also curates pathways that can be accessed by making choices in the drop down menu below. In addition SIGNOR offers advanced graph tools to explore the human cell network.

it looks for and displays interactions of te query entities all
it displays the interactions between the query entities connect
it displays the shortest weighted-path between the first and the second query entity find path

add bridge proteins
Search tips:
To search a single entity type its name or ID into the search bar.
For a multi-protein search type their Uniprot IDs or Gene Names separated by one of the following delimiters: comma(,), semi-colon(;), space.
Search tips:
type an article's PMID to view interactions curated from it
To view a pathway select it from the drop-down menu.

This tool draws networks connecting genes that have been associated to different diseases. The user can select within three different disease gene lists using the radio button below. The resulting connection-graphs can be displayed at three level of complexity. Level 1 (connect): only direct interactions between disease genes are shown. Level 2 (Add bridge proteins) disease genes that connect via bridge proteins are also shown. Level 3 (all): all the interactions of the disease genes annotated in SIGNOR are shown.
Select source of disease-gene lists: DisGeNet (v.7.0) IntoGen cancerCensus (v.92)