3.0
Neutrophils: Adhesion and migration
Pathway ID: SIGNOR-NeutroAMView in NDEx
Description: The neutrophils extravasation process is mediated by a multistep cascade of neutrophil adhesion to, and transmigration through, the vessel wall. Under resting conditions, neutrophils make temporary, reversible contactswith the endothelium which leads to a characteristic rolling phenomenon. This steady-state rolling is primarily mediated by the interaction of endothelial P-selectins with their neutrophil glycoprotein counterreceptors. The deceleration of neutrophils (slow rolling phase) is due to the expression of E-selectins on the inflamed endothelium.
Curated by: Alessandro Palma
Description: The neutrophils extravasation process is mediated by a multistep cascade of neutrophil adhesion to, and transmigration through, the vessel wall. Under resting conditions, neutrophils make temporary, reversible contactswith the endothelium which leads to a characteristic rolling phenomenon. This steady-state rolling is primarily mediated by the interaction of endothelial P-selectins with their neutrophil glycoprotein counterreceptors. The deceleration of neutrophils (slow rolling phase) is due to the expression of E-selectins on the inflamed endothelium.
Curated by: Alessandro Palma
