Pericyte: Prostaglandins and myogenesis

Pathway ID: SIGNOR-PPAMG

Description: Muscle regeneration is strongly dependent on prostaglandin pathways which can affect muscle cell proliferation, differentiation and fusion. Cycloxygenases (COX) use arachidonic acid to synthetize prostaglandins. Among them, COX-1 and COX-2 are the most highly expressed in damaged muscles and COX-2 is the most expressed in inflammatory cells.

Curated by: Alessandro Palma

13 Seed Entities

Organism:
Name Primary ID
IL4 P05112
Pravadoline CID:56463
SRF P11831
celecoxib CHEBI:41423
MYOD1 P15172
Proliferation SIGNOR-PH4
Myoblast_fusion SIGNOR-PH98
PTGS2 P35354
Skeletal_muscle_differentiation SIGNOR-PH1
prostaglandin F2alpha CHEBI:15553
acetylsalicylic acid CHEBI:15365
arachidonic acid CHEBI:15843
IL6 P05231