Satellite: Dystrophin glycoprotein complex regulation

Pathway ID: SIGNOR-ScDGC

Description: Satellite cell commitment depends on Myf5, which is transcriptionally activated by Pax7 after Carm1 methylation. Carm1 localization is regulated by p38gamma (MAPK12) which prevents its nuclear translocation by phosphorylating it. In normal satellite cells, this results in a physiological balance between symmetric and asymmetric cell division. In dystrophic cells, the loss of the interaction between p38gamma and beta-1-syntrophin favors Carm1 phosphorylation.

Curated by: Alessandro Palma

11 Seed Entities

Organism:
Name Primary ID
CARM1 Q86X55
MAPK12/CARM1 SIGNOR-C218
SNTB1 Q13884
MAPK12 P53778
MEF2A Q02078
MYF5 P13349
MYOD1 P15172
Skeletal_muscle_differentiation SIGNOR-PH1
DGC SIGNOR-C217
PAX7 P23759
Quiescence SIGNOR-PH25