| Name
|
 UBA6
|
| Full Name |
Ubiquitin-like modifier-activating enzyme 6 |
| Synonyms |
Ubiquitin-activating enzyme 6, Monocyte protein 4, MOP-4, Ubiquitin-activating enzyme E1-like protein 2, E1-L2 | MOP4, UBE1L2 |
| Primary ID |
A0AVT1 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Pathways |
Ubiquitin activation |
| Function |
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. |
3.0
binding