4.0
Summary
| Name |  DENND3View Modifications |
| Full Name | DENN domain-containing protein 3 |
| Synonyms | DEND3_HUMAN | KIAA0870 |
| Primary ID | A2RUS2 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ULK1 | up-regulates activity 
phosphorylation
|
DENND3 | 0.435 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | ULK2 | up-regulates activity
phosphorylation
|
DENND3 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | DENND3 | up-regulates activity
guanine nucleotide exchange factor
|
RAB12 | 0.624 |
| Publications: | 1 | Organism: | Homo Sapiens | |