| + |
PNP | up-regulates quantity 
chemical modification
|
inosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35063692 |
Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine salvage pathway. Inosine and guanosine and the respective deoxynucleosides are substrates of this enzyme. Adenosine and deoxyadenosine are mainly deaminated by adenosine deaminase respectively to inosine and deoxyinosine which are in turn catabolized by PNP |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hypoxanthine | up-regulates quantity
precursor of
|
inosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280552 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35063692 |
Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine salvage pathway. Inosine and guanosine and the respective deoxynucleosides are substrates of this enzyme. Adenosine and deoxyadenosine are mainly deaminated by adenosine deaminase respectively to inosine and deoxyinosine which are in turn catabolized by PNP |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
inosine | up-regulates quantity
precursor of
|
adenosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269734 |
|
|
in vitro |
|
| pmid |
sentence |
| 15926889 |
Adenosine deaminase (ADA; EC 3.5.4.4) catalyses the deamination of adenosine and 2′-deoxyadenosine to inosine and deoxyinosine. Two different isoenzymes of ADA designated as ADA1 and ADA2 were found in mammals and lower vertebrates |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
adenosine | up-regulates quantity
precursor of
|
inosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269736 |
|
|
in vitro |
|
| pmid |
sentence |
| 15926889 |
Adenosine deaminase (ADA; EC 3.5.4.4) catalyses the deamination of adenosine and 2′-deoxyadenosine to inosine and deoxyinosine. Two different isoenzymes of ADA designated as ADA1 and ADA2 were found in mammals and lower vertebrates |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
ADA | up-regulates quantity
chemical modification
|
inosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269737 |
|
|
in vitro |
|
| pmid |
sentence |
| 15926889 |
Adenosine deaminase (ADA; EC 3.5.4.4) catalyses the deamination of adenosine and 2′-deoxyadenosine to inosine and deoxyinosine. Two different isoenzymes of ADA designated as ADA1 and ADA2 were found in mammals and lower vertebrates |
|
| Publications: |
1 |
Organism: |
In Vitro |
4.0
inosine