| + |
phosphatidylglycerol(1-) | up-regulates activity 
chemical activation
|
CRLS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267029 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16678169 |
The mitochondrial phospholipid cardiolipin is synthesized from cytidinediphosphate-diacylglycerol and phosphatidylglycerol, a process catalyzed by the enzyme cardiolipin synthase. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PTPMT1 | up-regulates
chemical modification
|
phosphatidylglycerol(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267025 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21641550 |
PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. We further demonstrate that PTPMT1 specifically dephosphorylates PGP in vitro. Loss of PTPMT1 leads to dramatic diminution of cardiolipin, which can be partially reversed by the expression of catalytic active PTPMT1. Our study identifies PTPMT1 as the mammalian PGP phosphatase and points to its role as a regulator of cardiolipin biosynthesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate(3-) | up-regulates quantity
precursor of
|
phosphatidylglycerol(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267027 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21641550 |
PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. We further demonstrate that PTPMT1 specifically dephosphorylates PGP in vitro. Loss of PTPMT1 leads to dramatic diminution of cardiolipin, which can be partially reversed by the expression of catalytic active PTPMT1. Our study identifies PTPMT1 as the mammalian PGP phosphatase and points to its role as a regulator of cardiolipin biosynthesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
phosphatidylglycerol(1-)