| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282522 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 37356666 |
Acetoacetyl-CoA synthetase (AACS) is the key enzyme in the anabolic utilization of ketone bodies (KBs) for denovo lipid synthesis, a process that bypasses citrate and ATP citrate lyase. Acetoacetyl-CoA (AcAc-CoA) synthetase (AACS) (AcAc-CoA ligase, Enzyme Commission no.: 6.2.1.16) is a cytosolic lipogenic enzyme found in many tissues involved in lipid synthesis (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11). It catalyzes the coupling of acetoacetate (AcAc), one of the ketone bodies (KBs), to CoA in the reaction shown below to produce cytosolic AcAc-CoA. |
|
ATP(4-)
4.0
chemical modification