Summary

Name E2F3
Full Name Transcription factor E2F3
Synonyms E2F-3 | KIAA0075
Primary ID O00716
Links - -
Type protein
Relations 2
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation E2F3 0.332
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TFDP1 0.731
Publications: 1 Organism: Cricetulus Griseus