+ |
PTPRT | down-regulates activity
dephosphorylation
|
STAT3 |
0.535 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263981 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
HCT-116 Cell, HT-29 Cell |
pmid |
sentence |
17360477 |
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T|Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PTPRT | down-regulates activity
dephosphorylation
|
PXN |
0.478 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263978 |
Tyr88 |
PQSSSPVyGSSAKTS |
Homo sapiens |
HT-29 Cell |
pmid |
sentence |
27447856 |
To this end, using a phospho-proteomics approach, we identified and validated paxillin and STAT3 as the substrates of PTPRT [15, 16]|the PTPRT target site on paxillin is a previously uncharacterized tyrosine-88 residue (paxillin Y88)|In this study, we also show how pY88 paxillin transduces a signal to activate Akt |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FYN | down-regulates activity
phosphorylation
|
PTPRT |
0.429 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275543 |
Tyr915 |
Y-->K |
|
|
pmid |
sentence |
19816407 |
Synapse formation by PTPRT was inhibited by phosphorylation of tyrosine 912 within the membrane-proximal catalytic domain of PTPRT by Fyn. This tyrosine phosphorylation reduced phosphatase activity of PTPRT |
|
Publications: |
1 |