+ |
ATXN7 | form complex
binding
|
SAGA complex |
0.663 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269576 |
|
|
Homo sapiens |
|
pmid |
sentence |
34811519 |
Here we present the cryogenic-electron microscopy (cryo-EM) structure of human SAGA (hSAGA)|Human SAGA is a 20-subunit, 1.4-MDa complex with five functional modules (Fig. (Fig.1a):1a): a scaffolding core that includes TBP-associated factors (TAFs); a TRRAP (Transformation/Transcription domain Associated Protein) containing a phosphoinositide-3-kinase (PI3K)-related pseudoprotein kinase (ΨPIKK); a histone acetyltransferase (HAT); a deubiquitinase (DUB) and a metazoan-specific splicing (SPL) module |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ATXN7 | down-regulates activity
binding
|
CRX |
0.627 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-223226 |
|
|
Mus musculus |
|
pmid |
sentence |
11580893 |
We found that ataxin-7 and CRX colocalize and coimmunoprecipitate. We observed that polyglutamine-expanded ataxin-7 can dramatically suppress CRX transactivation. |
|
Publications: |
1 |
Organism: |
Mus Musculus |