3.0
Summary
| Name |  KCNN4View Modifications |
| Full Name | Intermediate conductance calcium-activated potassium channel protein 4 |
| Synonyms | SK4, SKCa 4, SKCa4, IKCa1, IK1, KCa3.1, KCa4, Putative Gardos channel | IK1, IKCA1, KCA4, SK4 |
| Primary ID | O15554 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Inhibitors | clotrimazole; nitrendipine |
| Function | Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NME2 | up-regulates 
phosphorylation
|
KCNN4 | 0.437 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | clotrimazole | down-regulates activity 
chemical inhibition
|
KCNN4 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | nitrendipine | down-regulates activity
chemical inhibition
|
KCNN4 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRAM-34 | up-regulates
chemical activation
|
KCNN4 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Naphtho[1,2-d]thiazol-2-amine | up-regulates activity
chemical activation
|
KCNN4 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Riluzole | up-regulates activity
chemical activation
|
KCNN4 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |