Summary

Name LAMTOR5
Full Name Ragulator complex protein LAMTOR5
Synonyms Hepatitis B virus X-interacting protein, HBV X-interacting protein, HBX-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 | HBXIP, XIP
Primary ID O43504
Links - -
Type protein
Relations 4
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding LAMTOR5 0.332
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation S100A4 0.372
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding LAMTOR 0.893
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LIN28B 0.254
Publications: 1 Organism: Homo Sapiens