Summary

Name PSTPIP1
Full Name Proline-serine-threonine phosphatase-interacting protein 1
Synonyms PEST phosphatase-interacting protein 1, CD2-binding protein 1, H-PIP | CD2BP1
Primary ID O43586
Links - -
Type protein
Relations 7
Function Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation PSTPIP1 0.636
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation PSTPIP1 0.622
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PSTPIP1 0.622
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/indirect_inhibition.png ABL1 0.622
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PTPN18 0.587
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png binding DNM2 0.383
Publications: 1 Organism: Homo Sapiens