3.0
Summary
| Name |  PRC1View Modifications |
| Full Name | Protein regulator of cytokinesis 1 |
| Synonyms | PRC1_HUMAN |
| Primary ID | O43663 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CyclinE/CDK2 |
phosphorylation
|
PRC1 | 0.352 |
| Publications: | 2 | |||
| + | CyclinY/CDK16 | up-regulates activity 
phosphorylation
|
PRC1 | 0.351 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK16 | up-regulates activity
phosphorylation
|
PRC1 | 0.351 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRC1 | up-regulates activity
binding
|
KIF23 | 0.593 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRC1 | up-regulates 
|
Spindle_assembly | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRC1 | up-regulates activity
binding
|
KIF14 | 0.616 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRC1 | up-regulates activity
binding
|
CENPE | 0.606 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KIF4A | up-regulates activity
binding
|
PRC1 | 0.589 |
| Publications: | 1 | Organism: | Homo Sapiens | |