Summary

Name ATP9A
Full Name Probable phospholipid-transporting ATPase IIA
Synonyms ATPase class II type 9A | ATPIIA, KIAA0611
Primary ID O75110
Links - -
Type protein
Relations 1
Function Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation (PubMed:27733620, PubMed:30213940, PubMed:36604604). Also involved in endosome to trans-Golgi network retrograde transport (PubMed:27733620, PubMed:30213940). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation (PubMed:30213940). Appears to be implicated in intercellular communication by negatively regulating the release of exosomes (PubMed:30947313). The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved (PubMed:30947313). Required for the maintenance of neurite morphology and synaptic transmission (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ ATP9Aform complex img/form-complex.png binding ATP9A-DOP1B-MON2, golgi transporter complex 0.48
Publications: 1 Organism: Homo Sapiens