3.0
Summary
| Name |  PSIP1View Modifications |
| Full Name | PC4 and SFRS1-interacting protein |
| Synonyms | CLL-associated antigen KW-7, Dense fine speckles 70 kDa protein, DFS 70, Lens epithelium-derived growth factor, Transcriptional coactivator p75/p52 | DFS70, LEDGF, PSIP2 |
| Primary ID | O75475 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDC7 | up-regulates 
phosphorylation
|
PSIP1 | 0.341 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CASP3 | down-regulates 
cleavage
|
PSIP1 | 0.355 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Caspase 3 complex | down-regulates
cleavage
|
PSIP1 | 0.355 |
| Publications: | 1 | Organism: | Homo Sapiens | |